含新型毛果芸香碱聚合物盐的毛果芸香碱滴眼液（作者译）
[Pilocarpin eye drops with a novel Pilocarpin polymeric salt (author's transl)].
作者信息
Stodtmeister R, Brenner J, Baur M P
出版信息
Klin Monbl Augenheilkd. 1979 Feb;174(2):276-80.
A new pilocarpin salt was obtained by chemically linking pilocarpin to a polymere substance. By galenic processing to the respective emulsion, eye drops containing this pilocarpin salt were produced, which enable a retarded pilocarpin delivery in vitro. With respect to glaucoma therapy, clinical tests showed that frequency of application can considerably be reduced. In the present investigations on a collective of 30 normal volunteers the effect of a commercial aqueous pilocarpin solution on the IOP, pupillary diameter and accommodation was compared with that of the novel pilocarpin drops.
通过将毛果芸香碱与一种聚合物质进行化学连接，获得了一种新的毛果芸香碱盐。通过将其制成相应的乳剂进行药剂学加工，制备出了含有这种毛果芸香碱盐的滴眼液，该滴眼液在体外能够实现毛果芸香碱的缓释。对于青光眼治疗，临床试验表明应用频率可大幅降低。在对30名正常志愿者群体的当前研究中，将一种市售毛果芸香碱水溶液对眼压、瞳孔直径和调节功能的影响与新型毛果芸香碱滴眼液的影响进行了比较。
Zotero 插件