Hibaoui Lahbib, Massik Abdelhamid, Yahyaoui Ghita, Mahmoud Mustapha, Hmass Naoual, Chbani Laila, Lakhdar Idrissi Mounia, Hida Moustapha
Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, MAR.
Department of Microbiology and Molecular Biology, Hassan II University Hospital, Fez, MAR.
Cureus. 2023 Jun 21;15(6):e40740. doi: 10.7759/cureus.40740. eCollection 2023 Jun.
Infesting nearly half of the world's population, is thought to cause peptic ulcers and gastric adenocarcinoma. Several studies have examined the association between and socioeconomic, clinical, and histological factors in pediatric populations. Similarly, this study aimed to describe the characteristics of infection in Moroccan children.
Patients aged 1-17 years who underwent upper gastrointestinal endoscopy over a period of two years from January 2019 to January 2021 were included in this study. Gastric biopsies from the antrum and corpus of the stomach were collected. Detection of infection was confirmed by Giemsa stain. Demographic data and clinical and endoscopic characteristics were collected and histopathological findings with gastritis scoring were recorded according to the Sydney System.
In 213 children, 95 (45%) were found to be infected with , and the infection rates increased as the children aged. While no significant relationship between the infection of and all symptoms was founded, a significant association was found in nodular gastritis (p<0.05), and 98% of the infected children had chronic inflammation, which was active in 22% and atrophic in 47%. The atrophy and activity were absent or mild, and the inflammation was mild to moderate.
According to this study, nodular gastritis and nonspecific symptoms were related to infection in Moroccan children. In addition, the association between this disease and gastric atrophy in our study needs the monitoring of the mucosa of Moroccan children with gastritis and identifying factors that may contribute to gastric cancer.
幽门螺杆菌感染全球近一半人口，被认为会导致消化性溃疡和胃腺癌。多项研究探讨了幽门螺杆菌与儿科人群社会经济、临床和组织学因素之间的关联。同样，本研究旨在描述摩洛哥儿童幽门螺杆菌感染的特征。
纳入2019年1月至2021年1月期间接受上消化道内镜检查的1至17岁患者。采集胃窦和胃体的胃活检组织。通过吉姆萨染色确认幽门螺杆菌感染的检测。收集人口统计学数据以及临床和内镜特征，并根据悉尼系统记录胃炎评分的组织病理学结果。
在213名儿童中，发现95名（45%）感染了幽门螺杆菌，感染率随着儿童年龄增长而增加。虽然未发现幽门螺杆菌感染与所有症状之间存在显著关系，但在结节性胃炎中发现了显著关联（p<0.05），98%的感染儿童患有慢性炎症，其中22%为活动性炎症，47%为萎缩性炎症。萎缩和活动性不存在或较轻，炎症为轻度至中度。
根据本研究，结节性胃炎和非特异性症状与摩洛哥儿童幽门螺杆菌感染有关。此外，本研究中该疾病与胃萎缩之间的关联需要对摩洛哥胃炎儿童的黏膜进行监测，并确定可能导致胃癌的因素。
