Laboratory of Helicobacter pylori and Gastric Pathologies, Institut Pasteur du Maroc, Casablanca 20360, Morocco.
Laboratory of Biotechnology and Valorization of Plant Resources, Faculty of Sciences, Chouaib Doukkali University, El Jadida 24000, Morocco.
Pan Afr Med J. 2024 Jul 4;48:89. doi: 10.11604/pamj.2024.48.89.43271. eCollection 2024.
the prevalence of Helicobacter pylori (H. pylori) infection in children is very high in Morocco. Eradication rates of H. pylori infection decrease due to the emergence of resistance to antibiotics. Data on the antimicrobial susceptibility of H. pylori in Moroccan children are not available. This study aims to assess the prevalence of H. pylori infection and the metronidazole resistance rate of H. pylori in Moroccan pediatric patients, and their association with epidemiologic factors.
a cross-sectional study was conducted on 132 pediatric patients who had an indication for upper gastrointestinal endoscopy and attended pediatric hospital Abderrahim Harouchi of the University Hospital Ibn Rochd, Casablanca, Morocco. Detection of H. pylori infection and the susceptibility to metronidazole was performed by classic PCR. Statistical analysis was performed using R Studio software.
the overall prevalence of H. pylori infection was 80.3%. vomiting was significantly associated with H. pylori infection (p-value=0.01). Regarding the resistance rate of metronidazole, we found that the prevalence of H. pylori resistance to metronidazole was high (70.8%) and it significantly increased, especially in pediatric patients living in urban areas (p-value=0.01).
the prevalence of H. pylori infection and resistance rate of metronidazole were very high in Moroccan children. Therefore, triple therapy with metronidazole must be preceded by a study of the bacterium's susceptibility to the prescribed antibiotics, in particular to metronidazole.
在摩洛哥，儿童中幽门螺杆菌（H. pylori）感染的流行率非常高。由于抗生素耐药性的出现，H. pylori 感染的根除率下降。关于摩洛哥儿童中 H. pylori 的抗菌药物敏感性数据尚不可用。本研究旨在评估摩洛哥儿科患者 H. pylori 感染的流行率和甲硝唑耐药率及其与流行病学因素的关系。
对 132 例有上消化道内镜检查指征并在摩洛哥卡萨布兰卡大学医院 Abderrahim Harouchi 儿科医院就诊的儿科患者进行了横断面研究。通过经典 PCR 检测 H. pylori 感染和甲硝唑敏感性。使用 R Studio 软件进行统计分析。
H. pylori 感染的总流行率为 80.3%。呕吐与 H. pylori 感染显著相关（p 值=0.01）。关于甲硝唑耐药率，我们发现 H. pylori 对甲硝唑的耐药率很高（70.8%），尤其是在居住在城市地区的儿科患者中显著增加（p 值=0.01）。
在摩洛哥儿童中，H. pylori 感染的流行率和甲硝唑耐药率非常高。因此，甲硝唑三联疗法必须在研究细菌对规定抗生素的敏感性，特别是甲硝唑的敏感性之前进行。
