通过计算流体动力学模型测量的冠状动脉微血管阻力中的性别差异。
Sex differences in coronary microvascular resistance measured by a computational fluid dynamics model.
作者信息
Taylor Daniel J, Aubiniere-Robb Louise, Gosling Rebecca, Newman Tom, Hose D Rodney, Halliday Ian, Lawford Patricia V, Narracott Andrew J, Gunn Julian P, Morris Paul D
机构信息
Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom.
Department of Cardiology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom.
出版信息
Front Cardiovasc Med. 2023 Jul 6;10:1159160. doi: 10.3389/fcvm.2023.1159160. eCollection 2023.
BACKGROUND
Increased coronary microvascular resistance (CMVR) is associated with coronary microvascular dysfunction (CMD). Although CMD is more common in women, sex-specific differences in CMVR have not been demonstrated previously.
AIM
To compare CMVR between men and women being investigated for chest pain.
METHODS AND RESULTS
We used a computational fluid dynamics (CFD) model of human coronary physiology to calculate absolute CMVR based on invasive coronary angiographic images and pressures in 203 coronary arteries from 144 individual patients. CMVR was significantly higher in women than men (860 [650-1,205] vs. 680 [520-865] WU, = -2.24, = 0.025). None of the other major subgroup comparisons yielded any differences in CMVR.
CONCLUSION
CMVR was significantly higher in women compared with men. These sex-specific differences may help to explain the increased prevalence of CMD in women.
背景
冠状动脉微血管阻力（CMVR）增加与冠状动脉微血管功能障碍（CMD）相关。尽管CMD在女性中更为常见，但此前尚未证实CMVR存在性别差异。
目的
比较因胸痛接受检查的男性和女性之间的CMVR。
方法与结果
我们使用人体冠状动脉生理学的计算流体动力学（CFD）模型，根据侵入性冠状动脉血管造影图像和144例个体患者203条冠状动脉的压力计算绝对CMVR。女性的CMVR显著高于男性（860[650 - 1205]与680[520 - 865] WU， = -2.24， = 0.025）。其他主要亚组比较在CMVR方面均未产生差异。
结论
女性的CMVR显著高于男性。这些性别差异可能有助于解释女性CMD患病率增加的原因。
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