Tamamoto-Mochizuki Chie, Santoro Domenico, Saridomikelakis Manolis N, Eisenschenk Melissa N C, Hensel Patrick, Pucheu-Haston Cherie
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.
Vet Dermatol. 2024 Feb;35(1):25-39. doi: 10.1111/vde.13192. Epub 2023 Jul 23.
Cytokines and chemokines play central roles in the pathogenesis of canine atopic dermatitis (cAD). Numerous studies have been published and provide new insights into their roles in cAD.
To summarise the research updates on the role of cytokines and chemokines in the pathogenesis of cAD since the last review by the International Committee on Allergic Diseases of Animals in 2015.
Online citation databases, abstracts and proceedings from international meetings on cytokines and chemokines relevant to cAD that had been published between 2015 and 2022 were reviewed.
Advances in technologies have allowed the simultaneous analysis of a broader range of cytokines and chemokines, which revealed an upregulation of a multipolar immunological axis (Th1, Th2, Th17 and Th22) in cAD. Most studies focused on specific cytokines, which were proposed as potential novel biomarkers and/or therapeutic targets for cAD, such as interleukin-31. Most other cytokines and chemokines had inconsistent results, perhaps as a consequence of their varied involvement in the pathogenesis of different endotypes of cAD.
Inconsistent results for many cytokines and chemokines illustrate the difficulty of studying the complex cytokine and chemokine networks in cAD, and highlight the need for more comprehensive and structured studies in the future.
细胞因子和趋化因子在犬特应性皮炎（cAD）的发病机制中起核心作用。已有大量研究发表，为它们在cAD中的作用提供了新见解。
总结自2015年动物过敏性疾病国际委员会上次综述以来，细胞因子和趋化因子在cAD发病机制中作用的研究进展。
回顾了2015年至2022年间发表的与cAD相关的细胞因子和趋化因子的在线引文数据库、摘要及国际会议论文集。
技术进步使得能够同时分析更广泛的细胞因子和趋化因子，这揭示了cAD中多极免疫轴（Th1、Th2、Th17和Th22）的上调。大多数研究聚焦于特定细胞因子，如白细胞介素-31，它们被提议作为cAD潜在的新型生物标志物和/或治疗靶点。大多数其他细胞因子和趋化因子的结果不一致，这可能是由于它们在不同cAD内型发病机制中的参与情况各异。
许多细胞因子和趋化因子结果不一致，说明了研究cAD中复杂的细胞因子和趋化因子网络的困难，并突出了未来进行更全面、结构化研究的必要性。
