Department of Chemistry, Soochow University, No. 70, Linhsi Road, Shihlin District, Taipei 111002, Taiwan.
National Synchrotron Radiation Research Centre, Hsinchu 30076, Taiwan.
Chem Commun (Camb). 2023 Aug 8;59(64):9774-9777. doi: 10.1039/d3cc02784h.
-Nitrosothiols (SNOs) serve as endogenous carriers and donors of NO within living cells, releasing nitrosonium ions (NO), NO, or other nitroso derivatives. In this study, we present a bioinspired {Co(NO)} complex 1 that achieved -nitrosation towards Cys residues. The incorporation of a ferrocenyl group in 1 allowed for fine-tuning of the nitrosation reaction, taking advantage of the redox ability of Cys residues. Complex 1 was synthesized and characterized, demonstrating its NO translation reactivity. Furthermore, complex 1 successfully converted Cys into -nitrosocysteine (Cys-SNO), as confirmed by UV-Vis, IR, and XAS spectroscopy. This study presents a promising approach for -nitrosation of Cys residues for further exploration in the modification of Cys-containing peptides.
