Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil.
Psychiatry Res. 2023 Aug;326:115353. doi: 10.1016/j.psychres.2023.115353. Epub 2023 Jul 17.
Delivering electroconvulsive therapy (ECT) during the reconsolidation of traumatic memories may enhance the treatment efficacy in posttraumatic stress disorder (PTSD). To test this, 14 patients with severe and refractory PTSD were randomly allocated to receive ECT sessions either after retrieving the traumatic (n=8) or a neutral (n=6) memory. We found that delivering ECT after retrieving the traumatic memory enhanced the improvement of PTSD symptoms and the reduction of subjective reactivity to the traumatic memory. Reduction in anxiety and mood symptoms and physiological reactivity to the traumatic memory were observed in the sample as a whole regardless of memory retrieval.
在创伤记忆的再巩固期间给予电抽搐治疗（ECT）可能会增强创伤后应激障碍（PTSD）的治疗效果。为了验证这一点，14 名患有严重和难治性 PTSD 的患者被随机分配接受 ECT 治疗，分别在检索创伤性记忆（n=8）或中性记忆（n=6）后进行。我们发现，在检索创伤性记忆后给予 ECT 治疗可增强 PTSD 症状的改善，并减少对创伤性记忆的主观反应。无论是否检索记忆，整个样本中均观察到焦虑和情绪症状的减轻以及对创伤性记忆的生理反应。
