PHARMO Institute for Drug Outcomes Research, Utrecht, and Amsterdam UMC location Vrije Universiteit Amsterdam, General Practice, Amsterdam, the Netherlands.
Amsterdam UMC location Vrije Universiteit Amsterdam, General Practice, Amsterdam, and Amsterdam Public Health, Amsterdam, the Netherlands.
Br J Gen Pract. 2023 Sep 28;73(735):e752-e759. doi: 10.3399/BJGP.2022.0574. Print 2023 Oct.
Routinely collected clinical data based on electronic medical records could be used to define frailty.
To estimate the ability of four potential frailty measures that use electronic medical record data to identify older patients who were frail according to their GP.
This retrospective cohort study used data from 36 GP practices in the Dutch PHARMO Data Network.
The measures were the Dutch Polypharmacy Index, Charlson Comorbidity Index (CCI), Chronic Disease Score (CDS), and Frailty Index. GPs' clinical judgement of patients' frailty status was considered the reference standard. Performance of the measures was assessed with the area under the receiver operating characteristic curve (AUC). Analyses were done in the total population and stratified by age and sex.
Of 31 511 patients aged ≥65 years, 3735 (11.9%) patients were classified as frail by their GP. The CCI showed the highest AUC (0.79, 95% confidence interval [CI] = 0.78 to 0.80), followed by the CDS (0.69, 95% CI = 0.68 to 0.70). Overall, the measures showed poorer performance in males and females aged ≥85 years than younger age groups (AUC 0.55-0.58 in females and 0.57-0.60 in males).
This study showed that of four frailty measures based on electronic medical records in primary care only the CCI had an acceptable performance to assess frailty compared with frailty assessments done by professionals. In the youngest age groups diagnostic performance was acceptable for all measures. However, performance declined with older age and was least accurate in the oldest age group, thereby limiting the use in patients of most interest.
基于电子病历的常规临床数据可用于定义衰弱。
评估四种潜在的基于电子病历数据的衰弱测量方法,以识别根据全科医生判断衰弱的老年患者。
这是一项回顾性队列研究,使用了荷兰 PHARMO 数据网络中的 36 个全科医生实践的数据。
这些措施是荷兰多药指数、Charlson 合并症指数(CCI)、慢性疾病评分(CDS)和衰弱指数。全科医生对患者衰弱状态的临床判断被认为是参考标准。使用接收者操作特征曲线下面积(AUC)评估措施的性能。在总人群中以及按年龄和性别分层进行了分析。
在 31511 名≥65 岁的患者中,3735 名(11.9%)患者被其全科医生归类为衰弱。CCI 的 AUC 最高(0.79,95%置信区间[CI] = 0.78 至 0.80),其次是 CDS(0.69,95% CI = 0.68 至 0.70)。总体而言,这些措施在≥85 岁的男性和女性中的表现不如年轻年龄组(女性 AUC 为 0.55-0.58,男性为 0.57-0.60)。
本研究表明,在初级保健中,基于电子病历的四种衰弱测量方法中,只有 CCI 与专业人员进行的衰弱评估相比具有可接受的性能来评估衰弱。在最年轻的年龄组中,所有措施的诊断性能都是可以接受的。然而,随着年龄的增长,性能下降,在最年长的年龄组中准确性最低,从而限制了对最感兴趣的患者的使用。