脊椎动物基因密码子第三位的G + C含量多样性及其成因。
Diversity in G + C content at the third position of codons in vertebrate genes and its cause.
作者信息
Aota S, Ikemura T
出版信息
Nucleic Acids Res. 1986 Aug 26;14(16):6345-55. doi: 10.1093/nar/14.16.6345.
Abstract
Correlation was positive between the G + C content at the codon third position in genes of vertebrates and the G + C content of the genome portion surrounding each gene. Exons of genes with a high G + C% at the codon 3rd position are surrounded by G + C-rich introns and G + C-rich flanking sequences, and those with a low G + C% at the position by A + T-rich introns and flanking sequences. Analysis of G + C content distribution along DNA sequences using a DNA Sequence Data Bank supported the view that the vertebrate genome is a mosaic of regions with clear differences in their G + C content. The biological significance of the variation in G + C content throughout the vertebrate genome is discussed in connection with chromosomal banding.
摘要
脊椎动物基因密码子第三位的G + C含量与每个基因周围基因组部分的G + C含量之间呈正相关。密码子第三位G + C%高的基因外显子被富含G + C的内含子和富含G + C的侧翼序列所包围，而该位置G + C%低的基因外显子则被富含A + T的内含子和侧翼序列所包围。利用DNA序列数据库对DNA序列上G + C含量分布进行分析，支持了脊椎动物基因组是由G + C含量存在明显差异的区域镶嵌而成的观点。结合染色体带型，讨论了整个脊椎动物基因组中G + C含量变化的生物学意义。
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