School of Biochemistry and Immunology, TBSI, Trinity College Dublin, Dublin, Ireland.
Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nat Metab. 2023 Jul;5(7):1088-1100. doi: 10.1038/s42255-023-00846-3. Epub 2023 Jul 20.
In mammals, interleukin (IL)-17 cytokines are produced by innate and adaptive lymphocytes. However, the IL-17 family has widespread expression throughout evolution, dating as far back as cnidaria, molluscs and worms, which predate lymphocytes. The evolutionary conservation of IL-17 suggests that it is involved in innate defence strategies, but also that this cytokine family has a fundamental role beyond typical host defence. Throughout evolution, IL-17 seems to have a major function in homeostatic maintenance at barrier sites. Most recently, a pivotal role has been identified for IL-17 in regulating cellular metabolism, neuroimmunology and tissue physiology, particularly in adipose tissue. Here we review the emerging role of IL-17 signalling in regulating metabolic processes, which may shine a light on the evolutionary role of IL-17 beyond typical immune responses. We propose that IL-17 helps to coordinate the cross-talk among the nervous, endocrine and immune systems for whole-body energy homeostasis as a key player in neuroimmunometabolism.
在哺乳动物中，白细胞介素 (IL)-17 细胞因子由先天和适应性淋巴细胞产生。然而，IL-17 家族在整个进化过程中广泛表达，甚至可以追溯到比淋巴细胞更早出现的刺胞动物、软体动物和蠕虫。IL-17 的进化保守性表明它参与了先天防御策略，但也表明该细胞因子家族在典型的宿主防御之外具有基本作用。在整个进化过程中，IL-17 似乎在屏障部位的稳态维持中具有主要功能。最近，IL-17 在调节细胞代谢、神经免疫和组织生理学方面，特别是在脂肪组织中的作用被确定为关键。在这里，我们综述了 IL-17 信号在调节代谢过程中的新兴作用，这可能揭示了 IL-17 在超越典型免疫反应的进化中的作用。我们提出，IL-17 有助于协调神经系统、内分泌系统和免疫系统之间的对话，以维持全身能量稳态，作为神经免疫代谢中的关键参与者。
