Robinson A B
Mech Ageing Dev. 1979 Feb;9(3-4):225-36. doi: 10.1016/0047-6374(79)90101-5.
It has been hypothesized that the deamidation of glutaminyl and asparaginyl residues serves as a molecular clock for many biological processes including protein turnover, development, and aging. At present, this hypothesis has passed some experimental tests which are necessary but not sufficient for its acceptance. The current state of evidence about deamidation as a molecular clock is discussed. In addition, since the molecular biology of aging, especially in humans, is only partly understood, it is of value to develop quantitative, empirical measures of physiological human age and to use these measures to evaluate alternative human living conditions, especially easily adopted alternatives like variations in diet. This may allow some decrease in the suffering and loss from human aging until such time as molecular biology provides superior and more intellectually satisfying answers. An empirical system which consists of quantitative measurement of several hundred human chemical constituents followed by computerized pattern recognition is described. It is hoped that this system will eventually become an aid in the minimization of the rate of human aging through changes in diet and other factors.
有人提出假说，谷氨酰胺和天冬酰胺残基的脱酰胺作用是许多生物过程的分子时钟，这些过程包括蛋白质周转、发育和衰老。目前，这一假说已经通过了一些实验检验，这些检验虽有必要，但不足以使其被接受。本文讨论了脱酰胺作用作为分子时钟的现有证据状态。此外，由于衰老的分子生物学，尤其是人类衰老的分子生物学，目前仅部分为人所知，因此开发定量的、基于经验的生理人类年龄测量方法，并使用这些方法来评估不同的人类生活条件，尤其是像饮食变化这样易于采用的替代条件，是很有价值的。这可能会在一定程度上减少人类衰老带来的痛苦和损失，直到分子生物学提供更优越、更令人满意的答案。本文描述了一个经验系统，该系统包括对数百种人体化学成分进行定量测量，然后进行计算机化模式识别。希望这个系统最终能够通过饮食和其他因素的改变，帮助降低人类衰老的速度。
