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Multiple forms of cytochrome c in the rat. Precursor-product relationship between the main component Cy I and the minor components Cy II and Cy 3 in vivo.大鼠体内细胞色素c的多种形式。体内主要成分Cy I与次要成分Cy II和Cy 3之间的前体-产物关系。
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Rates of nonenzymatic deamidation of glutaminyl and asparaginyl residues in pentapeptides.五肽中谷氨酰胺基和天冬酰胺基残基的非酶促脱酰胺速率。
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Deamidation of glutaminyl and asparaginyl residues in peptides and proteins.肽和蛋白质中谷氨酰胺残基和天冬酰胺残基的脱酰胺作用。
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肽和蛋白质中谷氨酰胺和天冬酰胺残基及其近邻的分布。

Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.

作者信息

Robinson A B, Robinson L R

机构信息

Oregon Institute of Science and Medicine, Cave Junction 97523.

出版信息

Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):8880-4. doi: 10.1073/pnas.88.20.8880.

DOI:10.1073/pnas.88.20.8880
PMID:1924347
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC52614/
Abstract

In a statistical study of neighboring residues in 1465 peptides and proteins comprising 450,431 residues, it was found that the preferences for residues neighboring to glutamine and asparagine residues are consistent with the hypothesis that the rates of deamidation of these residues are of biological significance. Some dipeptide and tripeptide structures have special usefulness and some are especially undesirable. More such structures exist for amide residues than for other residues, and their specific types are those most relevant to the deamidation of amide residues under biological conditions.

摘要

在一项对包含450,431个残基的1465种肽和蛋白质中相邻残基的统计研究中，发现谷氨酰胺和天冬酰胺残基相邻残基的偏好与这些残基的脱酰胺速率具有生物学意义这一假设一致。一些二肽和三肽结构具有特殊用途，而一些则特别不理想。酰胺残基的此类结构比其他残基更多，并且其特定类型是与生物条件下酰胺残基脱酰胺最相关的那些。