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When It Comes to COVID-19, Inflammation Is All the RAGE.

作者信息

Katsoulis Orestis, Guo Rui, Singanayagam Aran

机构信息

Department of Infectious Disease Imperial College London London, United Kingdom.

Department of Critical Care Medicine The First Affiliated Hospital of Chongqing Medical University Chongqing, China.

出版信息

Am J Respir Cell Mol Biol. 2023 Nov;69(5):489-490. doi: 10.1165/rcmb.2023-0227ED.

DOI:10.1165/rcmb.2023-0227ED
PMID:37489933
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10633835/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c36/10633835/5c4a45490e9c/rcmb.2023-0227EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c36/10633835/5c4a45490e9c/rcmb.2023-0227EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c36/10633835/5c4a45490e9c/rcmb.2023-0227EDf1.jpg

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A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.持续性中性粒细胞相关免疫特征可作为新冠病毒感染后肺部后遗症的标志物。
Sci Transl Med. 2022 Nov 16;14(671):eabo5795. doi: 10.1126/scitranslmed.abo5795.
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Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation.
高致病性冠状病毒 N 蛋白通过 MASP-2 介导的凝集素补体途径过度激活加重炎症。
Signal Transduct Target Ther. 2022 Sep 14;7(1):318. doi: 10.1038/s41392-022-01133-5.
4
SARS-CoV-2 pathogenesis.严重急性呼吸综合征冠状病毒 2 型的发病机制。
Nat Rev Microbiol. 2022 May;20(5):270-284. doi: 10.1038/s41579-022-00713-0. Epub 2022 Mar 30.
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SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice NF-ĸB Activation.SARS-CoV-2 N 蛋白诱导小鼠急性肺损伤 NF-ĸB 活化。
Front Immunol. 2021 Dec 7;12:791753. doi: 10.3389/fimmu.2021.791753. eCollection 2021.
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SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation.SARS-CoV-2 N 蛋白促进 NLRP3 炎性小体激活诱导过度炎症。
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