Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou 510642, China.
Food Funct. 2023 Aug 14;14(16):7347-7360. doi: 10.1039/d3fo01403g.
Although astaxanthin has been shown to have high potential for weight loss, the specific action site and signal pathway generally cannot be confirmed in other animal models. This prevents us from finding therapeutic targets. Hence, we further illuminated its efficacy and specific action sites by using (). In this study, 60 μM astaxanthin supplementation reduced overall fat deposition and triglyceride levels by 21.47% and 22.00% ( < 0.01). The content of large lipid droplets was reversed after astaxanthin treatment, and the ratio of oleic acid/stearic acid (C18:1Δ9/C18:0) decreased significantly, which were essential substrates for triglyceride biosynthesis. In addition, astaxanthin prevented obesity caused by excessive energy accumulation and insufficient energy consumption. Furthermore, the above effects were induced by / and insulin/insulin-like growth factor pathways, and finally co-regulated the specific site- and down-regulation. These results provided insight into therapeutic targets for future astaxanthin as a nutritional health product to relieve obesity.
尽管虾青素在减肥方面显示出了很高的潜力，但在其他动物模型中，其特定的作用部位和信号通路通常无法得到确认。这使得我们无法找到治疗靶点。因此，我们使用（）进一步阐明了其疗效和特定的作用部位。在这项研究中，60 μM 的虾青素补充剂将总脂肪沉积和甘油三酯水平分别降低了 21.47%和 22.00%（<0.01）。虾青素处理后大脂滴的含量得到了逆转，油酸/硬脂酸（C18:1Δ9/C18:0）的比例显著下降，这是甘油三酯生物合成的必要底物。此外，虾青素预防了由于能量积累过多和消耗不足引起的肥胖。此外，上述作用是通过/和胰岛素/胰岛素样生长因子途径诱导的，最终共同调节了特定部位和的下调。这些结果为未来虾青素作为一种营养保健品来缓解肥胖提供了治疗靶点的见解。
