Department of Food Science, University of Massachusetts, Amherst, USA.
Food Funct. 2019 Aug 1;10(8):4966-4974. doi: 10.1039/c9fo00778d. Epub 2019 Jul 25.
trans-Trismethoxy resveratrol (TMR) is a methyl analog of resveratrol. It is found to exhibit enhanced biological effects compared to resveratrol, such as inhibition of cancer cell growth and pro-apoptotic activities. However, the role of TMR in lipid metabolism is not fully understood. In this study, we used Caenorhabditis elegans, an in vivo nematode model which has been widely applied in disease research, including research on obesity, to investigate the effect of TMR on lipid metabolism. Treatment with TMR (100 and 200 μM) for 4 days significantly reduced triglyceride accumulation (14% and 20% reduction over the control, respectively) of C. elegans, without affecting nematode growth, food intake and reproduction. Treatment with TMR significantly downregulated stearoyl-CoA desaturase genes, fat-6 and fat-7, accompanied by a decrease in the desaturation index of fatty acids, the ratio of oleic acid to stearic acid. These results suggest that TMR inhibits fat accumulation by downregulating stearoyl-CoA desaturase in C. elegans.
反式-三甲氧基白藜芦醇（TMR）是白藜芦醇的甲基类似物。与白藜芦醇相比，它表现出增强的生物学效应，如抑制癌细胞生长和促凋亡活性。然而，TMR 在脂代谢中的作用尚不完全清楚。在这项研究中，我们使用秀丽隐杆线虫，一种已广泛应用于疾病研究的活体线虫模型，包括肥胖症研究，来研究 TMR 对脂代谢的影响。用 TMR（100 和 200 μM）处理 4 天可显著减少秀丽隐杆线虫的甘油三酯积累（分别比对照组减少 14%和 20%），而不影响线虫的生长、食物摄入和繁殖。TMR 处理显著下调硬脂酰辅酶 A 去饱和酶基因 fat-6 和 fat-7，同时脂肪酸的去饱和指数（油酸与硬脂酸的比值）降低。这些结果表明，TMR 通过下调秀丽隐杆线虫中的硬脂酰辅酶 A 去饱和酶来抑制脂肪积累。
