Department of Family Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.
PLoS One. 2023 Jul 25;18(7):e0289123. doi: 10.1371/journal.pone.0289123. eCollection 2023.
Functional gastrointestinal disorders (FGIDs), also known as disorders of gut-brain interaction, occur not only in the elderly but also in young adults. This study aimed to evaluate the association between mental health conditions and FGIDs among Vietnamese new-entry medical students.
This cross-sectional study was conducted in February 2022 among new-entry medical students in Ho Chi Minh City, Vietnam. A printed questionnaire was distributed to all students on the day of freshmen health screening. Their urine samples were collected to screen for Helicobacter pylori infection using rapid urinary test. FGIDs were diagnosed using ROME IV criteria. Gastroesophageal reflux disease (GERD) was defined as the presence of typical reflux symptoms at least twice a week. Mental health conditions, including generalized anxiety disorder (GAD) and major depressive disorder (MDD), were identified using Generalized Anxiety Disorder Assessment-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) scales, respectively.
Among 400 new-entry medical students who participated in the study, the overall prevalence of FGIDs was 10.3% (functional dyspepsia 6.5%, irritable bowel disease 5.5%). The overlap syndrome (OS) of GERD-FGIDs or different FGIDs was present in 3.0% of participants. The prevalences of GAD and MDD were 6.8% and 10.2%, respectively. The urinary test was positive in 180 (45.0%) participants. In the multivariable logistic regression analysis, MDD was significantly associated with not only the risk of FGIDs (OR = 5.599, 95%CI: 2.173-14.430, p<0.001) but also the risk of OS (OR = 10.076, 95CI%: 2.243-45.266, p = 0.003).
MDD is associated with FGIDs and OS among new-entry medical students.
功能性胃肠病（FGIDs），也称为肠脑互动障碍，不仅发生在老年人中，也发生在年轻成年人中。本研究旨在评估越南新入学医学生的心理健康状况与 FGIDs 之间的关联。
这是一项于 2022 年 2 月在越南胡志明市进行的横断面研究，对所有新生进行健康筛查当天，向所有学生分发了纸质问卷。采集他们的尿液样本，使用快速尿液测试筛查幽门螺杆菌感染。FGIDs 采用罗马 IV 标准诊断。胃食管反流病（GERD）定义为每周至少有两次典型反流症状。使用广义焦虑症评估-7（GAD-7）和患者健康问卷-9（PHQ-9）量表分别确定心理健康状况，包括广泛性焦虑症（GAD）和重度抑郁症（MDD）。
在 400 名参与研究的新入学医学生中，FGIDs 的总体患病率为 10.3%（功能性消化不良 6.5%，肠易激综合征 5.5%）。3.0%的参与者存在 GERD-FGIDs 重叠综合征（OS）或不同 FGIDs。GAD 和 MDD 的患病率分别为 6.8%和 10.2%。180 名（45.0%）参与者尿液检测呈阳性。在多变量逻辑回归分析中，MDD 与 FGIDs 风险（OR=5.599，95%CI：2.173-14.430，p<0.001）和 OS 风险（OR=10.076，95%CI%：2.243-45.266，p=0.003）显著相关。
MDD 与新入学医学生的 FGIDs 和 OS 相关。
