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Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies.

作者信息

Ochs Jasmin, Häusser-Kinzel Silke, Weber Martin S

机构信息

Institute of Neuropathology, University Medical Center, Göttingen, Germany.

Department of Neurology, University Medical Center, Göttingen, Germany.

出版信息

Nat Rev Immunol. 2023 Sep;23(9):539-540. doi: 10.1038/s41577-023-00920-7.

DOI:10.1038/s41577-023-00920-7

PMID:37491447

Abstract

摘要

相似文献

Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies.

Nat Rev Immunol. 2023 Sep;23(9):539-540. doi: 10.1038/s41577-023-00920-7.

Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes.

J Immunol. 2008 Dec 1;181(11):8120-32. doi: 10.4049/jimmunol.181.11.8120.

Role for ZAP-70 Signaling in the Differential Effector Functions of Rituximab and Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia B Cells.

J Immunol. 2017 Aug 15;199(4):1275-1282. doi: 10.4049/jimmunol.1602105. Epub 2017 Jul 14.

Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells.

J Immunol. 2007 Mar 15;178(6):3637-47. doi: 10.4049/jimmunol.178.6.3637.

Mechanism of Fcγ receptor-mediated trogocytosis-based false-positive results in flow cytometry.

PLoS One. 2012;7(12):e52918. doi: 10.1371/journal.pone.0052918. Epub 2012 Dec 27.

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus.

PLoS One. 2014 May 19;9(5):e98315. doi: 10.1371/journal.pone.0098315. eCollection 2014.

Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells.

Blood. 2008 Jun 15;111(12):5621-8. doi: 10.1182/blood-2008-01-134155. Epub 2008 Apr 1.

Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.

Cytometry A. 2011 Jan;79(1):46-56. doi: 10.1002/cyto.a.20984.

Trogocytosis with monocytes associated with increased α2,3 sialic acid expression on B cells during H5N1 influenza virus infection.

PLoS One. 2020 Sep 18;15(9):e0239488. doi: 10.1371/journal.pone.0239488. eCollection 2020.

Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments.

Blood. 2015 Jan 29;125(5):762-6. doi: 10.1182/blood-2014-10-569244. Epub 2014 Dec 10.

引用本文的文献

Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis with T cells.

PeerJ. 2025 Mar 31;13:e19236. doi: 10.7717/peerj.19236. eCollection 2025.

Programmable macromolecule delivery via engineered trogocytosis.

bioRxiv. 2025 Mar 14:2025.03.12.642522. doi: 10.1101/2025.03.12.642522.

Trogocytosis-mediated immune evasion in the tumor microenvironment.

Exp Mol Med. 2025 Feb;57(1):1-12. doi: 10.1038/s12276-024-01364-2. Epub 2025 Jan 1.

The origin of human CD20 T cells: a stolen identity?

Front Immunol. 2024 Nov 22;15:1487530. doi: 10.3389/fimmu.2024.1487530. eCollection 2024.

Therapeutic antibodies in oncology: an immunopharmacological overview.

Cancer Immunol Immunother. 2024 Oct 3;73(12):242. doi: 10.1007/s00262-024-03814-2.

Intercellular Transfer of Immune Regulatory Molecules Via Trogocytosis.

Results Probl Cell Differ. 2024;73:131-146. doi: 10.1007/978-3-031-62036-2_6.

The dual nature of T - bridging dendritic and T cells in immunity.

FEBS Lett. 2024 Aug 8. doi: 10.1002/1873-3468.14998.

Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.

Vet Res Commun. 2024 Apr;48(2):865-875. doi: 10.1007/s11259-023-10260-5. Epub 2023 Nov 16.

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Proinflammatory CD20 T cells contribute to CNS-directed autoimmunity.

Sci Transl Med. 2022 Mar 30;14(638):eabi4632. doi: 10.1126/scitranslmed.abi4632.

Antibody drug conjugate: the "biological missile" for targeted cancer therapy.

Signal Transduct Target Ther. 2022 Mar 22;7(1):93. doi: 10.1038/s41392-022-00947-7.

Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study.

Mult Scler Relat Disord. 2022 Jan;57:103352. doi: 10.1016/j.msard.2021.103352. Epub 2021 Oct 26.

Proinflammatory CD20 T Cells are Differentially Affected by Multiple Sclerosis Therapeutics.

Ann Neurol. 2021 Nov;90(5):834-839. doi: 10.1002/ana.26216. Epub 2021 Oct 2.

Targeting ADCC: A different approach to HER2 breast cancer in the immunotherapy era.

Breast. 2021 Dec;60:15-25. doi: 10.1016/j.breast.2021.08.007. Epub 2021 Aug 19.

A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20-Yet Progress Continues.

Neurotherapeutics. 2021 Jul;18(3):1602-1622. doi: 10.1007/s13311-021-01048-z. Epub 2021 Apr 20.

Trogocytosis between Non-Immune Cells for Cell Clearance, and among Immune-Related Cells for Modulating Immune Responses and Autoimmunity.

Int J Mol Sci. 2021 Feb 24;22(5):2236. doi: 10.3390/ijms22052236.

The significance of OX40 and OX40L to T-cell biology and immune disease.

Immunol Rev. 2009 May;229(1):173-91. doi: 10.1111/j.1600-065X.2009.00766.x.

Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand.

J Immunol. 2001 Jul 15;167(2):875-83. doi: 10.4049/jimmunol.167.2.875.

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Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies.

作者信息

Ochs Jasmin, Häusser-Kinzel Silke, Weber Martin S

机构信息

Institute of Neuropathology, University Medical Center, Göttingen, Germany.

Department of Neurology, University Medical Center, Göttingen, Germany.

出版信息

Nat Rev Immunol. 2023 Sep;23(9):539-540. doi: 10.1038/s41577-023-00920-7.

DOI:10.1038/s41577-023-00920-7

PMID:37491447

Abstract

摘要

相似文献

Trogocytosis challenges the cellular specificity of lineage markers and monoclonal antibodies.

Nat Rev Immunol. 2023 Sep;23(9):539-540. doi: 10.1038/s41577-023-00920-7.

Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes.

J Immunol. 2008 Dec 1;181(11):8120-32. doi: 10.4049/jimmunol.181.11.8120.

Role for ZAP-70 Signaling in the Differential Effector Functions of Rituximab and Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia B Cells.

J Immunol. 2017 Aug 15;199(4):1275-1282. doi: 10.4049/jimmunol.1602105. Epub 2017 Jul 14.

Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells.

J Immunol. 2007 Mar 15;178(6):3637-47. doi: 10.4049/jimmunol.178.6.3637.

Mechanism of Fcγ receptor-mediated trogocytosis-based false-positive results in flow cytometry.

PLoS One. 2012;7(12):e52918. doi: 10.1371/journal.pone.0052918. Epub 2012 Dec 27.

Anti-CD22/CD20 Bispecific antibody with enhanced trogocytosis for treatment of Lupus.

PLoS One. 2014 May 19;9(5):e98315. doi: 10.1371/journal.pone.0098315. eCollection 2014.

Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells.

Blood. 2008 Jun 15;111(12):5621-8. doi: 10.1182/blood-2008-01-134155. Epub 2008 Apr 1.

Plasma-dependent, antibody- and Fcγ receptor-mediated translocation of CD8 molecules from T cells to monocytes.

Cytometry A. 2011 Jan;79(1):46-56. doi: 10.1002/cyto.a.20984.

Trogocytosis with monocytes associated with increased α2,3 sialic acid expression on B cells during H5N1 influenza virus infection.

PLoS One. 2020 Sep 18;15(9):e0239488. doi: 10.1371/journal.pone.0239488. eCollection 2020.

Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments.

Blood. 2015 Jan 29;125(5):762-6. doi: 10.1182/blood-2014-10-569244. Epub 2014 Dec 10.

引用本文的文献

Triple negative breast cancer cells acquire lymphocyte proteins and genomic DNA during trogocytosis with T cells.

PeerJ. 2025 Mar 31;13:e19236. doi: 10.7717/peerj.19236. eCollection 2025.

Programmable macromolecule delivery via engineered trogocytosis.

bioRxiv. 2025 Mar 14:2025.03.12.642522. doi: 10.1101/2025.03.12.642522.

Trogocytosis-mediated immune evasion in the tumor microenvironment.

Exp Mol Med. 2025 Feb;57(1):1-12. doi: 10.1038/s12276-024-01364-2. Epub 2025 Jan 1.

The origin of human CD20 T cells: a stolen identity?

Front Immunol. 2024 Nov 22;15:1487530. doi: 10.3389/fimmu.2024.1487530. eCollection 2024.

Therapeutic antibodies in oncology: an immunopharmacological overview.

Cancer Immunol Immunother. 2024 Oct 3;73(12):242. doi: 10.1007/s00262-024-03814-2.

Intercellular Transfer of Immune Regulatory Molecules Via Trogocytosis.

Results Probl Cell Differ. 2024;73:131-146. doi: 10.1007/978-3-031-62036-2_6.

The dual nature of T - bridging dendritic and T cells in immunity.

FEBS Lett. 2024 Aug 8. doi: 10.1002/1873-3468.14998.

Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.

Vet Res Commun. 2024 Apr;48(2):865-875. doi: 10.1007/s11259-023-10260-5. Epub 2023 Nov 16.

本文引用的文献

Proinflammatory CD20 T cells contribute to CNS-directed autoimmunity.

Sci Transl Med. 2022 Mar 30;14(638):eabi4632. doi: 10.1126/scitranslmed.abi4632.

Antibody drug conjugate: the "biological missile" for targeted cancer therapy.

Signal Transduct Target Ther. 2022 Mar 22;7(1):93. doi: 10.1038/s41392-022-00947-7.

Inebilizumab for treatment of neuromyelitis optica spectrum disorder in patients with prior rituximab use from the N-MOmentum Study.

Mult Scler Relat Disord. 2022 Jan;57:103352. doi: 10.1016/j.msard.2021.103352. Epub 2021 Oct 26.

Proinflammatory CD20 T Cells are Differentially Affected by Multiple Sclerosis Therapeutics.

Ann Neurol. 2021 Nov;90(5):834-839. doi: 10.1002/ana.26216. Epub 2021 Oct 2.

Targeting ADCC: A different approach to HER2 breast cancer in the immunotherapy era.

Breast. 2021 Dec;60:15-25. doi: 10.1016/j.breast.2021.08.007. Epub 2021 Aug 19.

A Milestone in Multiple Sclerosis Therapy: Monoclonal Antibodies Against CD20-Yet Progress Continues.

Neurotherapeutics. 2021 Jul;18(3):1602-1622. doi: 10.1007/s13311-021-01048-z. Epub 2021 Apr 20.

Trogocytosis between Non-Immune Cells for Cell Clearance, and among Immune-Related Cells for Modulating Immune Responses and Autoimmunity.

Int J Mol Sci. 2021 Feb 24;22(5):2236. doi: 10.3390/ijms22052236.

The significance of OX40 and OX40L to T-cell biology and immune disease.

Immunol Rev. 2009 May;229(1):173-91. doi: 10.1111/j.1600-065X.2009.00766.x.

Functional CD4 T cells after intercellular molecular transfer of 0X40 ligand.

J Immunol. 2001 Jul 15;167(2):875-83. doi: 10.4049/jimmunol.167.2.875.