代谢相关脂肪性肝病与肠道微生物群。
Metabolic-Associated Fatty Liver Disease and the Gut Microbiota.
机构信息
Division of Biomedical Sciences, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
Division of Biomedical Sciences, Warwick Medical School, Clinical Sciences Research Laboratories, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK; Warwickshire Institute for the Study of Diabetes, Endocrinology and Metabolism, University Hospitals Coventry and Warwickshire, Clifford Bridge Road, Coventry CV2 2DX, UK.
出版信息
Endocrinol Metab Clin North Am. 2023 Sep;52(3):485-496. doi: 10.1016/j.ecl.2023.01.004. Epub 2023 Mar 1.
As an important sequela of the burgeoning global obesity problem, metabolic-associated fatty liver disease (MAFLD) has gained increasing prominence recently. The gut-liver axis (GLA) provides a direct conduit to the liver for the gut microbiota and their metabolic by-products (including secondary bile acids, ethanol, and trimethylamine). These GLA-related factors, including the host inflammatory response and integrity of the gut mucosal wall, likely contribute to the pathogenesis of MAFLD. Accordingly, these GLA-related factors are targets for possible preventive and treatment strategies for MAFLD, and include probiotics, prebiotics, bile acids, short-chain fatty acids, fecal microbiota transplantation, carbon nanoparticles, and bacteriophages.
作为日益严重的全球肥胖问题的重要后遗症，代谢相关脂肪性肝病（MAFLD）最近受到了越来越多的关注。肠-肝轴（GLA）为肠道微生物群及其代谢产物（包括次级胆汁酸、乙醇和三甲胺）向肝脏提供了直接途径。这些与 GLA 相关的因素，包括宿主炎症反应和肠道黏膜壁的完整性，可能有助于 MAFLD 的发病机制。因此，这些与 GLA 相关的因素是 MAFLD 可能的预防和治疗策略的靶点，包括益生菌、益生元、胆汁酸、短链脂肪酸、粪便微生物群移植、碳纳米粒子和噬菌体。
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