Bhupesh Semwal, Chauhan Neha, Jyoti Verma, Ankit Kumar, Sonia Singh, Bhupendra Singh
Institute of Pharmaceutical Research, GLA University, Mathura, U.P. 281406, India.
Curr Mol Med. 2025;25(2):113-131. doi: 10.2174/1566524023666230727093911.
Diabetic nephropathy is a progressive kidney disease that frequently results in end-stage renal disorders and is characterized by proteinuria, albuminuria, decreased filtration, and renal fibrosis. Despite the fact that there are a number of therapeutic alternatives available, DN continues to be the main contributor to end-stage renal disease. Therefore, significant innovation is required to enhance outcomes in DN patients.
Information was collected from online search engines like, Google Scholar, Web of Science, PubMed, Scopus, and Sci-Hub databases using keywords like diabetes, nephropathy, kidney disease, autophagy, etc. Results: Natural compounds have anti-inflammatory and antioxidant properties and impact various signaling pathways. They ameliorate kidney damage by decreasing oxidative stress, inflammatory process, and fibrosis and enhance the antioxidant system, most likely by activating and deactivating several signaling pathways. This review focuses on the role of metabolic memory and various signaling pathways involved in the pathogenesis of DN and therapeutic approaches available for the management of DN. Special attention is given to the various pathways modulated by the phytoconstituents.
糖尿病肾病是一种进行性肾脏疾病，常导致终末期肾脏疾病，其特征为蛋白尿、白蛋白尿、滤过功能下降和肾纤维化。尽管有多种治疗选择，但糖尿病肾病仍然是终末期肾病的主要原因。因此，需要重大创新来改善糖尿病肾病患者的治疗效果。
使用糖尿病、肾病、肾脏疾病、自噬等关键词，从谷歌学术、科学网、PubMed、Scopus和Sci-Hub数据库等在线搜索引擎收集信息。结果：天然化合物具有抗炎和抗氧化特性，并影响多种信号通路。它们通过降低氧化应激、炎症过程和纤维化来改善肾脏损伤，并增强抗氧化系统，很可能是通过激活和失活多种信号通路来实现的。本综述重点关注代谢记忆的作用以及参与糖尿病肾病发病机制的各种信号通路，以及可用于糖尿病肾病管理的治疗方法。特别关注植物成分调节的各种途径。
