Department of Nutrition-Dietetics, Lab of Clinical Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, Trikala, Greece.
Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Kallithea, Greece.
Nutr Cancer. 2023;75(9):1783-1794. doi: 10.1080/01635581.2023.2237688. Epub 2023 Jul 27.
Cancer patients are at risk of malnutrition, which influences their functional status, mental health (MH), and quality of life (QoL). This study aimed to examine the associations between nutritional status, functional capacity, and aspects of QoL in cancer patients, as well as the potential mediating role of depression and anxiety in these associations. Patients with various types of cancer ( = 152) were recruited from the Attikon University Hospital, Greece. Validated questionnaires were used to assess nutritional status (PG-SGA), QoL (SF-36 and EQ-5D-3L), functional capacity (ECOG), depression, and anxiety (HADS and BEDS). Handgrip strength (HGS) was also measured. Poor nutritional status was inversely associated with functional capacity, QoL, depression, and anxiety, after adjusting for confounding factors (all ≤ 0.05). Mediation analysis indicated a significant indirect effect of nutritional status on various parameters of functional capacity and QoL through depression and anxiety, after adjusting for age and sex. Mediated proportion ranged from 26.3-34% to 23.1-82.8% for functional capacity and QoL, respectively. A significant proportion of the effect of nutritional status on QoL and functional capacity can be partly attributed to psychological effects, highlighting the significance of integrating all aforementioned aspects in the nutritional intervention for cancer patients.
癌症患者存在营养不良风险，这会影响他们的功能状态、心理健康和生活质量。本研究旨在探讨癌症患者的营养状况、功能能力和生活质量各方面之间的关联，以及抑郁和焦虑在这些关联中的潜在中介作用。从希腊 Attikon 大学医院招募了各种类型癌症患者（n=152）。使用经过验证的问卷评估营养状况（PG-SGA）、生活质量（SF-36 和 EQ-5D-3L）、功能能力（ECOG）、抑郁和焦虑（HADS 和 BEDS）。还测量了握力（HGS）。在调整混杂因素后，不良营养状况与功能能力、生活质量、抑郁和焦虑呈负相关（均 P≤0.05）。在调整年龄和性别后，中介分析表明营养状况通过抑郁和焦虑对功能能力和生活质量的多个参数具有显著的间接影响。中介比例在功能能力和生活质量方面分别为 26.3-34%至 23.1-82.8%。营养状况对生活质量和功能能力的影响有相当大的一部分归因于心理影响，这突出了在癌症患者的营养干预中整合所有上述方面的重要性。
