Micek Agnieszka, Błaszczyk-Bębenek Ewa, Cebula Aneta, Godos Justyna, Konopka Kamil, Wąż Anna, Grosso Giuseppe
Statistical Laboratory, Faculty of Health Sciences, Jagiellonian University Medical College, 31-501, Cracow, Poland.
Department of Nutrition and Drug Research, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066, Cracow, Poland.
Aging Clin Exp Res. 2025 May 23;37(1):162. doi: 10.1007/s40520-025-03071-y.
Anxiety and depression are common mental health problems in cancer patients. At the same time, cancer patients often suffer from disease-related catabolic dysregulation and malnutrition. Emerging evidence has suggested the potential link between mental disorders and nutritional status.
This study summarised the evidence for the association of malnutrition with anxiety and depression in cancer patients.
A systematic search of PubMed and EMBASE databases was performed for observational studies published up to December 2024.
Forty-one articles were found eligible for inclusion in the systematic review, and twenty-nine in the meta-analysis. Compared with the normally nourished cancer patients, malnourished patients had a more than threefold (relative risk (RR) = 3.23, 95% CI 2.39, 4.38) and nearly twofold (RR = 1.87, 95% CI 1.48, 2.37) increased risk of depression and anxiety, respectively. Considering the studies that identified lower emotional status as a cause rather than an effect of malnutrition, the inverse association was confirmed only for depression (RR = 2.01, 95% CI 1.62, 2.49), but not for anxiety (RR = 1.38, 95% CI 0.68, 2.80). Finally, the standardised mean differences of the psychological scores showed significantly higher values in individuals with nutritional impairment compared to those with normal nutritional status (SMD = 0.69, 95% CI 0.50, 0.88 for depression and SMD = 0.54, 95% CI 0.26, 0.82 for anxiety).
Mental health problems such as anxiety and depression are associated with malnutrition in cancer patients.
焦虑和抑郁是癌症患者常见的心理健康问题。同时，癌症患者常患有与疾病相关的分解代谢失调和营养不良。新出现的证据表明了精神障碍与营养状况之间的潜在联系。
本研究总结了癌症患者营养不良与焦虑和抑郁之间关联的证据。
对PubMed和EMBASE数据库进行系统检索，查找截至2024年12月发表的观察性研究。
发现41篇文章符合纳入系统评价的标准，29篇符合荟萃分析的标准。与营养正常的癌症患者相比，营养不良的患者患抑郁症和焦虑症的风险分别增加了三倍多（相对风险（RR）=3.23，95%置信区间2.39，4.38）和近两倍（RR=1.87，95%置信区间1.48，2.37）。考虑到将较低情绪状态确定为营养不良的原因而非结果的研究，仅抑郁症存在反向关联得到证实（RR=2.01，95%置信区间1.62，2.49），而焦虑症不存在（RR=1.38，95%置信区间0.68，2.80）。最后，心理评分的标准化平均差异显示，与营养状况正常的个体相比，营养受损个体的心理评分值显著更高（抑郁症的标准化平均差异=0.69，95%置信区间0.50，0.88；焦虑症的标准化平均差异=0.54，95%置信区间0.26，0.82）。
焦虑和抑郁等心理健康问题与癌症患者的营养不良有关。
