Briving C, Hamberger A, Kjellstrand P, Rosengren L, Karlsson J E, Haglid K G
Scand J Work Environ Health. 1986 Jun;12(3):216-20. doi: 10.5271/sjweh.2155.
Mongolian gerbils were exposed to dichloromethane for three months by continuous inhalation at 210 ppm. Total free tissue amino acids, glutathione, and phosphoethanolamine were determined in the vermis posterior of the cerebellum and the frontal cerebral cortex. These two brain areas were chosen because humans occupationally exposed to dichloromethane have shown abnormalities in the electroencephalogram of the frontal part of the cerebral cortex. This study showed that long-term exposure of gerbils to dichloromethane (210 ppm) for three months leads to decreased levels of glutamate, gamma-aminobutyric acid, and phosphoethanolamine in the frontal cerebral cortex, while glutamine and gamma-aminobutyric acid are elevated in the posterior cerebellar vermis.
将蒙古沙鼠连续三个月吸入210 ppm的二氯甲烷。测定了小脑蚓部后部和额叶皮质中总游离组织氨基酸、谷胱甘肽和磷酸乙醇胺的含量。选择这两个脑区是因为职业性接触二氯甲烷的人在大脑额叶皮质的脑电图中显示出异常。本研究表明，沙鼠长期暴露于二氯甲烷（210 ppm）三个月会导致额叶皮质中谷氨酸、γ-氨基丁酸和磷酸乙醇胺水平降低，而谷氨酰胺和γ-氨基丁酸在小脑蚓部后部升高。
