Rosengren L E, Aurell A, Kjellstrand P, Haglid K G
Scand J Work Environ Health. 1985 Dec;11(6):447-55. doi: 10.5271/sjweh.2201.
Mongolian gerbils (Meriones ungiculatus) were continuously exposed by inhalation to 1,1,1-trichloroethane at 70, 210, or 1 000 ppm for three months, followed by a four-month postexposure solvent-free period. Concentrations of two astroglial proteins, S-100 and glial fibrillary acidic (GFA) protein, were then determined in different regions of the cerebral cortex. The main biochemical alterations induced after exposure to 210 and 1 000 ppm of 1,1,1-trichloroethane demonstrated a pronounced change in gerbil brain; increased concentrations of GFA protein were found in the cerebral sensorimotor cortex at both these exposure levels, an occurrence indicating astrogliosis in this brain region. These results suggest that 1,1,1-trichloroethane should not be regarded as harmless, particularly regarding neurotoxicity, as previously claimed.
将蒙古沙鼠（长爪沙鼠）连续三个月通过吸入方式暴露于浓度为70、210或1000 ppm的1,1,1-三氯乙烷中，随后有四个月的无溶剂暴露后时期。然后测定大脑皮质不同区域中两种星形胶质细胞蛋白，即S-100和胶质纤维酸性（GFA）蛋白的浓度。暴露于210 ppm和1000 ppm的1,1,1-三氯乙烷后引起的主要生化改变表明沙鼠大脑发生了明显变化；在这两个暴露水平下，大脑感觉运动皮质中GFA蛋白浓度均升高，这一现象表明该脑区发生了星形胶质细胞增生。这些结果表明，1,1,1-三氯乙烷不应像之前所声称的那样被视为无害，尤其是在神经毒性方面。
