Department of Urology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.
Department of Urology, Fukuoka University Faculty of Medicine, Fukuoka, Japan
Anticancer Res. 2023 Aug;43(8):3607-3613. doi: 10.21873/anticanres.16540.
BACKGROUND/AIM: The aim of the present study was to investigate the factors related to overactive bladder (OAB)-like symptoms in patients with bladder cancer.
This study included 59 patients who underwent transurethral resection of bladder tumor (TURBT). OAB-like symptoms were identified based on the Overactive Bladder Symptom Score (OABSS) and International Prostate Symptom Score (IPSS) questionnaires. The main outcome measures were elucidation of bladder cancer-related factors that might induce OAB-like symptoms.
Non-muscle invasive bladder cancer (NMIBC) was observed in 50 patients, and carcinoma in situ (CIS) was observed in 14 patients. OABSS total score, IPSS total score, and quality of life index were 5±3, 12±7 and 3±1, respectively. The OABSS question 1 score, indicating pollakisuria, was significantly higher in NMIBC patients with CIS than in those without CIS (presence of CIS vs. absence of CIS=1.0±0.6 : 0.5±0.6, p=0.02). IPSS question 4 score, indicating urgency (r=0.31, p=0.01), and OABSS question 4 score, indicating urgency incontinence (r=0.29, p=0.03), correlated significantly with the maximum bladder tumor diameter. Multivariate regression analysis demonstrated that presence of CIS in NMIBC cases correlated significantly with pollakisuria (p=0.02), and that maximum diameter of the bladder tumor correlated significantly with both urgency (p=0.04) and urgency incontinence (p=0.01).
CIS induced pollakisuria in NMIBC. Larger diameter bladder tumors induced both urgency and urgency incontinence. Patients with bladder cancer who present with pollakisuria might have CIS.
背景/目的：本研究旨在探讨膀胱癌患者出现膀胱过度活动症（OAB）样症状的相关因素。
本研究纳入了 59 例行经尿道膀胱肿瘤切除术（TURBT）的患者。OAB 样症状基于膀胱过度活动症症状评分（OABSS）和国际前列腺症状评分（IPSS）问卷进行评估。主要观察指标为阐明可能导致 OAB 样症状的膀胱癌相关因素。
50 例患者为非肌层浸润性膀胱癌（NMIBC），14 例患者为原位癌（CIS）。OABSS 总分、IPSS 总分和生活质量指数分别为 5±3、12±7 和 3±1。OABSS 问题 1 评分（尿频）在伴有 CIS 的 NMIBC 患者中明显高于不伴有 CIS 的患者（存在 CIS 与不存在 CIS=1.0±0.6：0.5±0.6，p=0.02）。IPSS 问题 4 评分（急迫性）（r=0.31，p=0.01）和 OABSS 问题 4 评分（急迫性尿失禁）（r=0.29，p=0.03）与最大膀胱肿瘤直径显著相关。多变量回归分析表明，NMIBC 病例中 CIS 的存在与尿频显著相关（p=0.02），而膀胱肿瘤的最大直径与急迫性和急迫性尿失禁均显著相关（p=0.04 和 p=0.01）。
CIS 可引起 NMIBC 患者出现尿频。较大直径的膀胱肿瘤可引起急迫性和急迫性尿失禁。出现尿频的膀胱癌患者可能存在 CIS。
