用于猴痘发病机制研究和临床前药物评价的人源皮肤芯片。
Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation.
机构信息
Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA; Vaccine and Infectious Disease Division, Fred Hutch Cancer Center, Seattle, WA, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Department of Dermatology, Columbia University Medical Center, New York, NY, USA.
出版信息
Trends Pharmacol Sci. 2023 Dec;44(12):865-868. doi: 10.1016/j.tips.2023.07.001. Epub 2023 Jul 26.
Abstract
Timely intervention of preventative and therapeutic measures abated a 2022 mpox global outbreak. However, the high transmissibility and unique pathological characteristics of mpox demand further investigation. Here, we discuss the potentials of human skin-on-a-chip as a valuable model for mpox disease evaluation, to achieve in-depth physiological understanding and desirable therapeutic predictive capabilities.
摘要
及时采取预防和治疗措施，遏制了 2022 年猴痘全球疫情的爆发。然而，猴痘的高传染性和独特的病理特征需要进一步研究。在这里，我们讨论了人体皮肤芯片作为评估猴痘疾病的有价值模型的潜力，以实现对生理的深入理解和理想的治疗预测能力。
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