School of Medicine, The University of Notre Dame Australia, Fremantle.
Centre for Molecular Medicine & Innovative Therapeutics.
Curr Opin Neurol. 2023 Oct 1;36(5):441-449. doi: 10.1097/WCO.0000000000001185. Epub 2023 Jul 24.
This review offers a contemporary clinical approach to the recognition, prevention and management of sarcopenia, and discusses recent clinically relevant advances in the aetiopathogenesis of muscle ageing that may lead to future therapeutic targets.
The key recent directions for sarcopenia are in the diagnosis, understanding molecular mechanisms and management. Regarding the recognition of the condition, it has become increasingly clear that different definitions hamper progress in understanding. Therefore, the Global Leadership in Sarcopenia has been established in 2022 to develop a universally accepted definition. Moreover, substantial work is occurring to understand the various roles and contribution of inflammation, oxidative stress, mitochondrial dysfunction and metabolic dysregulation on skeletal muscle function and ageing. Finally, the role of resistance-based exercise regimes has been continually emphasised. However, the role of protein supplementation and hormone replacement therapy (HRT) are still under debate, and current clinical trials are underway.
With the global ageing of our population, there is increasing emphasis on maintaining good health. Maintenance of skeletal muscle strength and function are key to preventing frailty, morbidity and death.
本文提供了一种当代临床方法，用于识别、预防和管理肌肉减少症，并讨论了肌肉老化发病机制方面的最新临床相关进展，这些进展可能为未来的治疗靶点提供依据。
肌肉减少症的关键新方向在于诊断、理解分子机制和管理。在识别该病症方面，不同的定义阻碍了人们对其的理解，因此，全球肌肉减少症领导组织于 2022 年成立，旨在制定一个被普遍接受的定义。此外，人们正在深入研究炎症、氧化应激、线粒体功能障碍和代谢紊乱对骨骼肌功能和衰老的各种作用和贡献。最后，强调了基于阻力的运动方案的作用。但是，蛋白质补充和激素替代疗法（HRT）的作用仍存在争议，目前正在进行临床试验。
随着全球人口老龄化，人们越来越重视保持健康。保持骨骼肌力量和功能是预防虚弱、发病和死亡的关键。
