Abellan van Kan G, André E, Bischoff Ferrari H A, Boirie Y, Onder G, Pahor M, Ritz P, Rolland Y, Sampaio C, Studenski S, Visser M, Vellas B
Gérontopôle, INSERM U558, University of Toulouse III, Toulouse, France.
J Nutr Health Aging. 2009 Oct;13(8):700-7. doi: 10.1007/s12603-009-0200-0.
In the presence of an aging population, public health priorities need to evolve. As the populations gets older, the already existing pathologies have become commonplace with specific geriatric clinical syndromes like frailty, mobility disability, or cognitive impairment, among others. Sarcopenia is a good example for which geriatricians, neurologists, physiologists, nutritionists and epidemiologists need to find a consensual definition and diagnostic tool as well as guidelines for the management of clinical trials and possible treatments. The Carla Sarcopenia Task Force, which met in the south of France (Toulouse) for an expert consensus meeting called "Les Entretiens du Carla", have addressed a series of existing issues to place Sarcopenia into a nosological context: a definition which should be a composite of a change in muscle mass and a change in strength/function depending on either a progressive and chronic wasting process or an acute onset of loss of muscle mass; a recommendation for DXA and the Short Physical Performance Battery as a clinical pragmatic approach of Sarcopenia; a differentiated approach for clinical studies according to prevention or treatment objectives and depending on the sub-groups and target populations; and finally, a summary of therapeutic strategies currently recommended. The aim of "Les Entretiens du Carla", based on an expert meeting panel, was to address a series of unsolved issues in the field of Sarcopenia by combining the expert opinion with a revision of the existing literature on the topic. Through this report, the reader will appreciate the determination to find conclusions on the various issues and further studies to be developed to determine the best multidisciplinary approach needed.
在人口老龄化的背景下，公共卫生重点需要与时俱进。随着人口老龄化，诸如衰弱、行动障碍或认知障碍等特定老年临床综合征中已有的病理状况变得司空见惯。肌肉减少症就是一个很好的例子，老年医学专家、神经学家、生理学家、营养学家和流行病学家需要为其找到一个共识性定义、诊断工具以及临床试验管理和可能治疗方法的指南。卡拉肌肉减少症特别工作组在法国南部（图卢兹）召开了一次名为“卡拉研讨会”的专家共识会议，探讨了一系列现有问题，以便将肌肉减少症纳入疾病分类范畴：一个定义，它应综合肌肉质量变化以及取决于渐进性和慢性消瘦过程或肌肉质量急性丧失的力量/功能变化；推荐使用双能X线吸收法（DXA）和简短体能测试电池作为肌肉减少症的临床实用方法；根据预防或治疗目标以及亚组和目标人群对临床研究采取差异化方法；最后，总结目前推荐的治疗策略。基于专家会议小组的“卡拉研讨会”旨在通过将专家意见与对该主题现有文献的修订相结合，解决肌肉减少症领域的一系列未解决问题。通过本报告，读者将体会到为就各种问题得出结论以及开展进一步研究以确定所需最佳多学科方法的决心。
