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使用Impella CP进行为期一周的支持治疗以治疗乳头肌破裂作为手术过渡:一例病例报告。

One-week Impella CP support for papillary muscle rupture as a bridge to surgery: a case report.

作者信息

Kawanami Shodai, Egami Yasuyuki, Nishino Masami, Tanouchi Jun

机构信息

Division of Cardiology, Osaka Rosai Hospital, 1179-3 Nagasone-cho, Sakai 591-8025, Japan.

出版信息

Eur Heart J Case Rep. 2023 Jul 3;7(7):ytad274. doi: 10.1093/ehjcr/ytad274. eCollection 2023 Jul.

Abstract

BACKGROUND

Papillary muscle rupture (PMR) is a catastrophic complication of acute myocardial infarction. However, the best timing and modality of circulatory support for surgery are unknown.

CASE SUMMARY

A 75-year-old man presented to the emergency room in our hospital for worsening shortness of breath accompanied by chest pain. Transthoracic echocardiograph showed severe mitral regurgitation (MR) with a flail posterior mitral valve leaflet, and coronary angiography demonstrated distal right coronary artery occlusion. We diagnosed as cardiogenic shock due to subacute myocardial infarction and ischaemic PMR. An Impella CP (Abiomed, Danvers, MA, USA) was introduced to improve haemodynamics. Despite the grade of MR was still severe, the mean blood pressure and pulmonary artery pressure improved 4 h after an Impella CP support. At day 8, the patient underwent elective mitral valve replacement with single coronary artery bypass grafting.

DISCUSSION

PMR is a rare but lethal complication of acute myocardial infarction. Expeditious surgical treatment offers the optimal chance of survival, but the post-operative mortality or morbidity is very high. Therefore, preoperative stabilization can be closely correlated with outcomes in these patients. It was reported that directly unloading the left ventricle by an Impella decreased wall stress, external work, and myocardial oxygen consumption. Therefore, an Impella can be the most suitable mechanical circulatory support for PMR. In conclusion, Impella CP alone can become one of the suitable bridges to surgery in the patients with PMR.

摘要

背景

乳头肌破裂(PMR)是急性心肌梗死的一种灾难性并发症。然而,手术循环支持的最佳时机和方式尚不清楚。

病例摘要

一名75岁男性因呼吸急促加重并伴有胸痛入住我院急诊室。经胸超声心动图显示严重二尖瓣反流(MR),二尖瓣后叶连枷样改变,冠状动脉造影显示右冠状动脉远端闭塞。我们诊断为亚急性心肌梗死和缺血性PMR所致的心源性休克。置入一台Impella CP(美国马萨诸塞州丹弗斯市Abiomed公司生产)以改善血流动力学。尽管MR程度仍很严重,但在Impella CP支持4小时后平均血压和肺动脉压有所改善。在第8天,患者接受了择期二尖瓣置换术并同期进行单支冠状动脉旁路移植术。

讨论

PMR是急性心肌梗死一种罕见但致命性并发症。迅速的手术治疗提供了最佳的生存机会,但术后死亡率或发病率非常高。因此,术前稳定病情与这些患者的预后密切相关。据报道,Impella通过直接减轻左心室负荷可降低壁应力、外部做功及心肌耗氧量。因此,Impella可能是PMR最合适的机械循环支持装置。总之,单独使用Impella CP可成为PMR患者合适的手术过渡方式之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2aab/10371041/81778fa12d18/ytad274f1.jpg

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