Miki Kazunori, Aizawa Yuki, Fujii Shoko, Karakama Jun, Fujita Kyohei, Sasaki Yoshiyuki, Nemoto Shigeru, Sumita Kazutaka
Department of Endovascular Surgery, Tokyo Medical and Dental University, Tokyo, Japan.
Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan.
J Neuroendovasc Ther. 2021;15(5):281-287. doi: 10.5797/jnet.oa.2020-0041. Epub 2020 Dec 2.
The purpose of this study was to evaluate the combination of a 100-cm long balloon-guiding catheter (BGC) and 40-cm long sheath in patients treated by mechanical thrombectomy for anterior circulation acute ischemic stroke.
The subjects were 77 consecutive patients treated by endovascular recanalization for anterior circulation occlusion from January 2011. After February 2018, 24 patients were treated by mechanical thrombectomy using a long BGC and long sheath (L-BGC group), and were compared with 53 patients treated before January 2018 using a normal BGC and sheath (S-BGC group). The baseline angiographical/clinical characteristics, main procedures, BGC insertion time, internal carotid artery (ICA) cartelization rate, recanalization rate, and clinical outcome were compared between L-BGC and S-BGC groups.
There was no significant difference in angiographical/clinical characteristics except for intravenous thrombolysis with recombinant tissue plasminogen activator (IVrtPA) treatment. In all, 22 patients were treated by combined technique (CoT) thrombectomy in the L-BGC group. The BGC insertion time was significantly shorter in the L-BGC group than in the S-BGC group (19 vs 13 minutes), and ICA catheterization of BGC was successful in the L-BGC group, whereas there were seven failures in the S-BGC group (100% vs 84%). The puncture-to-recanalization (PtoR) time was significantly shorter in the L-BGC group (90 vs 44 minutes). The successful recanalization (SR) rate was higher in the L-BGC group (96% vs 72%). Good outcomes (mRS 0-2) slightly increased in the L-BGC group (64% vs 49%). In the multivariable analysis, only CoT thrombectomy was associated with PtoR and SR.
The combination of a long BGC and long sheath results in rapid and stable BGC insertion to the ICA. CoT thrombectomy with these devices may be useful for SR and reducing the PtoR in anterior circulation mechanical thrombectomy.
本研究旨在评估在接受前循环急性缺血性卒中机械取栓治疗的患者中,100厘米长的球囊引导导管(BGC)与40厘米长的鞘管联合使用的效果。
研究对象为2011年1月起连续77例接受血管内再通治疗的前循环闭塞患者。2018年2月后,24例患者使用长BGC和长鞘管进行机械取栓治疗(长BGC组),并与2018年1月前使用普通BGC和鞘管治疗的53例患者(标准BGC组)进行比较。比较长BGC组和标准BGC组的基线血管造影/临床特征、主要操作、BGC插入时间、颈内动脉(ICA)插管成功率、再通率和临床结局。
除重组组织型纤溶酶原激活剂静脉溶栓(IVrtPA)治疗外,血管造影/临床特征无显著差异。长BGC组共有22例患者接受联合技术(CoT)取栓治疗。长BGC组的BGC插入时间明显短于标准BGC组(19分钟对13分钟),长BGC组BGC成功插入ICA,而标准BGC组有7例失败(100%对84%)。长BGC组的穿刺到再通(PtoR)时间明显更短(90分钟对44分钟)。长BGC组的成功再通(SR)率更高(96%对72%)。长BGC组的良好结局(改良Rankin量表0-2分)略有增加(64%对49%)。在多变量分析中,只有CoT取栓与PtoR和SR相关。
长BGC和长鞘管联合使用可实现BGC快速、稳定地插入ICA。使用这些器械进行CoT取栓可能有助于前循环机械取栓的SR并缩短PtoR。