Osifo B O, Lukanmbi F A, Bolodeoku J O
Trop Geogr Med. 1986 Sep;38(3):259-64.
Concentrations of serum folate, red cell folate and serum cobalamin were studied among 240 normal healthy Nigerian adolescents aged 12-17 years. Serum folate level was generally low with a mean of 2.8 nmol/l while red cell folate level was not low with a mean of 369 nmol/l. Mean serum cobalamin was 615 pmol/l. A negative significant correlation was observed between serum folate and red cell folate among the adolescents (r = 0.24). Another significant correlation was observed among the 14 year olds between red cell folate and serum cobalamin (r = 0.404). The folate parameters were significantly lower in the adolescents with HbAS genotype with mean serum folate of 2.2 nmol/l and red cell folate of 326 nmol/l but these differences were more marked among the girls. All the girls in the study had significantly higher serum cobalamin than the boys (p less than 0.001) but the advantage of this is not clear. These results suggest that serum cobalamin may be under some hormonal influences and the high values indicate that cobalamin may be involved in other metabolic functions from the puberty period.
对240名年龄在12至17岁之间的尼日利亚正常健康青少年的血清叶酸、红细胞叶酸和血清钴胺素浓度进行了研究。血清叶酸水平普遍较低，平均值为2.8纳摩尔/升，而红细胞叶酸水平不低，平均值为369纳摩尔/升。血清钴胺素平均值为615皮摩尔/升。在青少年中，血清叶酸与红细胞叶酸之间存在显著的负相关（r = 0.24）。在14岁的青少年中，红细胞叶酸与血清钴胺素之间也观察到另一个显著相关性（r = 0.404）。HbAS基因型的青少年的叶酸参数显著较低，血清叶酸平均值为2.2纳摩尔/升，红细胞叶酸为326纳摩尔/升，但这些差异在女孩中更为明显。研究中的所有女孩血清钴胺素均显著高于男孩（p小于0.001），但其优势尚不清楚。这些结果表明，血清钴胺素可能受到某些激素的影响，其高值表明钴胺素可能在青春期就参与了其他代谢功能。
