Chadefaux B, Cooper B A, Gilfix B M, Lue-Shing H, Carson W, Gavsie A, Rosenblatt D S
Service de biochimie, Hôpital Necker, Paris, France.
Clin Invest Med. 1994 Dec;17(6):540-50.
Serum levels of total homocysteine were studied in the following: 26 healthy adults; 79 hospitalised patients in whom serum cobalamin, serum folate, and erythrocyte folate were greater than 230 pmol/L, 12 nmol/L, and 600 nmol/L, respectively; 32 hospitalised patients whose serum cobalamin was less than 147 pmol/L, compared to 25 patients whose serum cobalamin was greater than 147 pmol/L but unmatched in any other parameter; and 194 patients in whom samples were sent for determination of cobalamin and folate from a neurological service. None of this last group had megaloblastic anaemia. There was a relationship between the elevated concentrations of total homocysteine in serum and low concentrations of serum cobalamin and of erythrocyte folate. This relationship was most evident in samples with serum cobalamin < 86 pmol/L and erythrocyte folate < 335 nmol/L, although elevated homocysteine levels were found in some samples where serum cobalamin and erythrocyte folate levels were greater than these. Serum folate correlated poorly with serum total homocysteine. There was only a poor-to-fair correlation of neutrophil lobe counts to total serum homocysteine.
26名健康成年人；79名住院患者，其血清钴胺素、血清叶酸和红细胞叶酸水平分别大于230 pmol/L、12 nmol/L和600 nmol/L；32名住院患者，其血清钴胺素水平低于147 pmol/L，与之对比的是25名血清钴胺素水平高于147 pmol/L但其他参数不匹配的患者；以及194名从神经科送检钴胺素和叶酸测定样本的患者。最后一组患者均无巨幼细胞贫血。血清中总同型半胱氨酸浓度升高与血清钴胺素及红细胞叶酸浓度降低之间存在关联。这种关联在血清钴胺素<86 pmol/L且红细胞叶酸<335 nmol/L的样本中最为明显，不过在一些血清钴胺素和红细胞叶酸水平高于这些值的样本中也发现了同型半胱氨酸水平升高的情况。血清叶酸与血清总同型半胱氨酸的相关性较差。中性粒细胞分叶计数与血清总同型半胱氨酸的相关性仅为较差至中等。
