Kashin Alexander D, Sedelnikova Mariya B, Uvarkin Pavel V, Ugodchikova Anna V, Luginin Nikita A, Sharkeev Yurii P, Khimich Margarita A, Bakina Olga V
Laboratory of Physics of Nanostructured Biocomposites, Institute of Strength Physics and Materials Science of SB RAS, Tomsk 634055, Russia.
Laboratory of Plasma Synthesis of Materials, Troitsk Institute for Innovation & Fusion Research, Moscow Region, Troitsk 108840, Russia.
Biomimetics (Basel). 2023 Jun 29;8(3):280. doi: 10.3390/biomimetics8030280.
The method of micro-arc oxidation has been utilized to synthesize a protective biocompatible coating for a bioresorbable orthopedic Mg implant. This paper presents the results of comprehensive research of micro-arc coatings based on diatomite-a biogenic material consisting of shells of diatom microalgae. The main focus of this study was the functionalization of diatomite-based micro-arc coatings by incorporating particles of titania (TiO) into them. Various properties of the resulting coatings were examined and evaluated. XRD analysis revealed the formation of a new magnesium orthosilicate phase-forsterite (MgSiO). It was established that the corrosion current density of the coatings decreased by 1-2 orders of magnitude after the inclusion of TiO particles, depending on the coating process voltage. The adhesion strength of the coatings increased following the particle incorporation. The processes of dissolution of both coated and uncoated samples in a sodium chloride solution were studied. The in vitro cell viability was assessed, which showed that the coatings significantly reduced the cytotoxicity of Mg samples.
微弧氧化方法已被用于为可生物吸收的骨科镁植入物合成一种具有生物相容性的保护涂层。本文展示了基于硅藻土（一种由硅藻微藻壳组成的生物源材料）的微弧涂层的综合研究结果。本研究的主要重点是通过将二氧化钛（TiO）颗粒掺入其中来实现基于硅藻土的微弧涂层的功能化。对所得涂层的各种性能进行了检测和评估。XRD分析揭示了一种新的原硅酸镁相——镁橄榄石（Mg₂SiO₄）的形成。结果表明，根据涂层工艺电压的不同，在掺入TiO颗粒后，涂层的腐蚀电流密度降低了1 - 2个数量级。掺入颗粒后，涂层的附着力增强。研究了涂层和未涂层样品在氯化钠溶液中的溶解过程。评估了体外细胞活力，结果表明涂层显著降低了镁样品的细胞毒性。
