Suominen Nelli T, Roger Michel, Faucher Marie-Claude, Syrjänen Kari J, Grénman Seija E, Syrjänen Stina M, Louvanto Karolina
Department of Obstetrics and Gynecology, Turku University Hospital, University of Turku, 20520 Turku, Finland.
Department of Obstetrics and Gynecology, Vaasa Central Hospital, 65130 Vaasa, Finland.
Curr Issues Mol Biol. 2023 Jul 12;45(7):5798-5810. doi: 10.3390/cimb45070366.
The host factors that influence father-to-child human papillomavirus (HPV) transmission remain unknown. This study evaluated whether human leukocyte antigen (HLA)-G alleles are important in father-to-child HPV transmission during the perinatal period. Altogether, 134 father-newborn pairs from the Finnish Family HPV Study were included. Oral, semen and urethral samples from the fathers were collected before the delivery, and oral samples were collected from their offspring at delivery and postpartum on day 3 and during 1-, 2- and 6-month follow-up visits. HLA-G alleles were tested by direct sequencing. Unconditional logistic regression was used to determine the association of the father-child HLA-G allele and genotype concordance with the father-child HPV prevalence and concordance at birth and during follow-up. HLA-G allele G01:01:03 concordance was associated with the father's urethral and child's oral high-risk (HR)-HPV concordance at birth (OR 17.00, 95% CI: 1.24-232.22). HLA-G allele G01:04:01 concordance increased the father's oral and child's postpartum oral any- and HR-HPV concordance with an OR value of 7.50 (95% CI: 1.47-38.16) and OR value of 7.78 (95% CI: 1.38-43.85), respectively. There was no association between different HLA-G genotypes and HPV concordance among the father-child pairs at birth or postpartum. To conclude, the HLA-G allele concordance appears to impact the HPV transmission between the father and his offspring.
影响人乳头瘤病毒（HPV）从父亲传播至子女的宿主因素尚不清楚。本研究评估了人类白细胞抗原（HLA）-G等位基因在围产期HPV从父亲传播至子女过程中是否起重要作用。芬兰家庭HPV研究共纳入了134对父亲-新生儿对。在分娩前采集父亲的口腔、精液和尿道样本，在分娩时、产后第3天以及1个月、2个月和6个月随访时采集其子女的口腔样本。通过直接测序检测HLA-G等位基因。采用无条件逻辑回归确定父子HLA-G等位基因和基因型一致性与出生时及随访期间父子HPV感染率和一致性之间的关联。HLA-G等位基因G01:01:03一致性与出生时父亲尿道和子女口腔高危（HR）-HPV一致性相关（比值比[OR]17.00，95%置信区间[CI]：1.24 - 232.22）。HLA-G等位基因G01:04:01一致性分别使父亲口腔和子女产后口腔任何HPV及HR-HPV一致性的OR值增加至7.50（95%CI：1.47 - 38.16）和7.78（95%CI：1.38 - 43.85）。不同HLA-G基因型与出生时或产后父子对之间的HPV一致性无关联。总之，HLA-G等位基因一致性似乎影响父亲与其子女之间的HPV传播。
