Tikhe Chinmay V, Issiaka Sare, Dong Yuemei, Kefi Mary, Tavadia Mihra, Bilgo Etienne, Corder Rodrigo M, Marshall John, Diabate Abdoulaye, Dimopoulos George
W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Johns Hopkins Malaria Research Institute, Baltimore, MD 21205, USA.
Sci Adv. 2024 Dec 6;10(49):eads3658. doi: 10.1126/sciadv.ads3658. Epub 2024 Dec 4.
Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium sp. Panama () kills insecticide-resistant mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of acts as a synergist to now used chemical insecticides across multiple classes. Moreover, reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione -transferases are essential for 's mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.
病媒蚊虫控制是疟疾控制的一个组成部分。在传播疟疾的蚊虫中，全球范围内杀虫剂抗性的出现已成为一个障碍，并迫切需要新的蚊虫控制方法。在这里，我们表明，一种源自土壤细菌巴拿马芽孢杆菌（Bacillus sp. Panama）的生物杀虫剂可以杀死具有杀虫剂抗性的蚊虫，无论其抗性机制如何。此外，亚致死剂量的该生物杀虫剂可作为增效剂，与目前使用的多种化学杀虫剂协同作用。此外，该生物杀虫剂以进一步减少传播的方式降低了媒介蚊虫的宿主寻找行为和疟原虫感染。蚊虫谷胱甘肽转移酶对于该生物杀虫剂的杀蚊机制至关重要。在布基纳法索进行的封闭田间试验，在不同的生态环境中进行，并得到数学模型的支持，现已证明其在广泛存在杀虫剂抗性的环境中控制疟疾的潜力。
