Laboratory of Polymer and Colors Chemistry and Technology, Department of Chemistry, Aristotle University of Thessaloniki, 541 24 Thessaloniki, Greece.
Mar Drugs. 2023 Jun 22;21(7):370. doi: 10.3390/md21070370.
Chitosan is a polysaccharide vastly examined in polymer science for its unique structure. In the present study, CS was derivatized with 2-methoxy-4vinylphenol (MVP) in four different ratios through a free radical reaction. The CS-MVP derivatives were characterized through FTIR, 1H-NMR, XRD, swelling, and solubility measurements. Owing to the enhanced antioxidant character of the MVP monomer, the antioxidant activity of the CS-MVP derivatives was assessed. In the optimum CS-MVP ratio, blends between CS and CS-MVP were prepared in ratios of 90:10, 80:20, 70:30, 60:40, 50:50, 40:60, 30:70, 20:80, and 10:90 /, and their miscibility was examined by scanning electron microscopy (SEM) and viscosity measurements. In the optimum ratios, highly concentrated inks were prepared, and their viscosity measurements revealed the successful formation of highly viscous gels with shear thinning behavior. These inks could be appropriate candidates for biomedical and drug delivery applications.
壳聚糖是一种多糖，因其独特的结构在聚合物科学中得到了广泛的研究。在本研究中，通过自由基反应，壳聚糖（CS）与 2-甲氧基-4-乙烯基苯酚（MVP）以四种不同的比例进行了衍生化。通过傅里叶变换红外光谱（FTIR）、1H-NMR、X 射线衍射（XRD）、溶胀和溶解度测量对 CS-MVP 衍生物进行了表征。由于 MVP 单体具有增强的抗氧化特性，因此评估了 CS-MVP 衍生物的抗氧化活性。在最佳的 CS-MVP 比例下，CS 和 CS-MVP 之间的共混物以 90:10、80:20、70:30、60:40、50:50、40:60、30:70、20:80 和 10:90 的比例进行制备，并通过扫描电子显微镜（SEM）和粘度测量来研究它们的混溶性。在最佳比例下，制备了高浓度的墨水，其粘度测量结果表明，成功形成了具有剪切变稀行为的高粘性凝胶。这些墨水可能是生物医学和药物输送应用的合适候选物。
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