Fischer R
Pneumologische Praxis München-Pasing, Gleichmannstr. 5, 81241, München, Deutschland,
Internist (Berl). 2014 Mar;55(3):268-73. doi: 10.1007/s00108-013-3368-7.
Due to the decreasing partial pressure of oxygen, high altitude sickness can occur at heights over 2,500 m. This can be best avoided by slow adaptation to the altitude (acclimatization). In this way the organism adapts to the chronic hyperventilation and in the further process the oxygen content is normalized by an increase in erythrocytes. The commonest form of high altitude sickness is acute mountain sickness which is characterized by the leading symptom of headache. When additional signs of ataxia occur there is an acute danger of edema which is associated with a high mortality. Stress dyspnea, coughing and rasping breathing noises also occur by the potentially fatal high altitude pulmonary edema. All forms of high altitude sickness can be countered by a rapid descent to a height of at least 500 m. In acute mountain sickness acetazolamide can be administered (2 × 250 mg), for high altitude cerebral edema dexamethasone (3 × 4-8 mg) and for high altitude pulmonary edema nifedipine (initially 10 mg then 20 mg retard).
由于氧气分压降低,海拔超过2500米时可能会发生高原病。通过缓慢适应海拔高度(习服)可最好地避免这种情况。通过这种方式,机体适应慢性过度通气,在进一步的过程中,红细胞增加使氧含量恢复正常。高原病最常见的形式是急性高山病,其主要症状为头痛。当出现共济失调的其他体征时,存在水肿的急性危险,且水肿与高死亡率相关。应激性呼吸困难、咳嗽和刺耳的呼吸声也可能由潜在致命的高原肺水肿引起。所有形式的高原病都可通过迅速下降到至少500米的高度来应对。对于急性高山病,可服用乙酰唑胺(2×250毫克),对于高原脑水肿,可使用地塞米松(3×4 - 8毫克),对于高原肺水肿,可使用硝苯地平(初始剂量10毫克,然后缓释片20毫克)。