Du Mu, Qiu Mingfang, Qian Ye, Wang Tianqi, Chen Xiaobo
Department of Endocrinology, Children's Hospital of Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, 100020, Beijing, People's Republic of China.
Biol Trace Elem Res. 2024 Apr;202(4):1539-1549. doi: 10.1007/s12011-023-03790-1. Epub 2023 Jul 28.
To assess the association between serum copper/zinc ratio (CZR) and overweight/obesity in children. Sociodemographic and clinical data of children aged 8-18 years old were extracted from the National Health and Nutrition Examination Survey (NHANES) database in this cross-sectional study. These associations were explored using weighted univariate and multivariate logistic regression analyses with the odds ratios (ORs) and 95% confidence intervals (CIs). High serum CZR level was related to higher odds of overweight (OR = 1.74), obesity (OR = 5.26), and central obesity (OR = 2.99). Subgroup analyses showed that high serum CZR levels were associated with high odds of overweight in children aged ≥ 12 years old (OR = 2.19) and females (OR = 2.02), while the increased odds of obesity and central obesity were found in children aged ≥ 12 years old and both male and female. Elevated serum CZR level was linked to high odds of childhood overweight, obesity, and central obesity, and this relationship was also found in children with different age and gender.
评估儿童血清铜/锌比值（CZR）与超重/肥胖之间的关联。在这项横断面研究中，从国家健康与营养检查调查（NHANES）数据库中提取了8至18岁儿童的社会人口统计学和临床数据。使用加权单变量和多变量逻辑回归分析以及比值比（OR）和95%置信区间（CI）来探究这些关联。血清CZR水平高与超重（OR = 1.74）、肥胖（OR = 5.26）和中心性肥胖（OR = 2.99）的较高几率相关。亚组分析表明，血清CZR水平高与≥12岁儿童（OR = 2.19）和女性（OR = 2.02）超重的高几率相关，而在≥12岁儿童以及男性和女性中均发现肥胖和中心性肥胖的几率增加。血清CZR水平升高与儿童超重、肥胖和中心性肥胖的高几率相关，并且在不同年龄和性别的儿童中也发现了这种关系。
Zotero 插件