Division of Pulmonary and Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
Division of Gastroenterology, Boston Children's Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Semin Immunol. 2023 Sep;69:101815. doi: 10.1016/j.smim.2023.101815. Epub 2023 Jul 26.
Inflammasomes are cytoplasmic organelles that stimulate inflammation upon cellular detection of infectious or non-infectious stress. While much foundational work has focused on the infection-associated aspects of inflammasome activities, recent studies have highlighted the role of inflammasomes in non-infectious cellular and organismal functions. Herein, we discuss the evolution of inflammasome components and highlight characteristics that permit inflammasome regulation of physiologic processes. We focus on emerging data that highlight the importance of inflammasome proteins in the regulation of reproduction, development, and malignancy. A framework is proposed to contextualize these findings.
炎症小体是细胞质细胞器，当细胞检测到感染或非感染性应激时，会刺激炎症反应。虽然大量基础工作集中在炎症小体活动与感染相关的方面，但最近的研究强调了炎症小体在非感染性细胞和机体功能中的作用。在此，我们讨论了炎症小体成分的进化，并强调了允许炎症小体调节生理过程的特征。我们重点介绍了一些新数据，这些数据强调了炎症小体蛋白在调节生殖、发育和恶性肿瘤中的重要性。提出了一个框架来使这些发现具有背景。
