Emerg Infect Dis. 2023 Sep;29(9):1765-1771. doi: 10.3201/eid2909.230080. Epub 2023 Jul 28.
Streptococcus pneumoniae can co-infect persons who have viral respiratory tract infections. However, research on S. pneumoniae infections that are temporally associated with SARS-CoV-2 infections is limited. We described the epidemiology and clinical course of patients who had invasive pneumococcal disease (IPD) and temporally associated SARS-CoV-2 infections in Alaska, USA, during January 1, 2020-December 23, 2021. Of 271 patients who had laboratory-confirmed IPD, 55 (20%) had a positive SARS-CoV-2 test result. We observed no major differences in age, race, sex, or underlying medical conditions among IPD patients with and without SARS-CoV-2. However, a larger proportion of IPD patients with SARS-CoV-2 died (16%, n = 9) than for those with IPD alone (4%, n = 9) (p<0.01). IPD patients with SARS-CoV-2 were also more likely to be experiencing homelessness (adjusted OR 3.5; 95% CI 1.7-7.5). Our study highlights the risk for dual infection and ongoing benefits of pneumococcal and COVID-19 vaccination, especially among vulnerable populations.
肺炎链球菌可使同时患有病毒性呼吸道感染的人发生合并感染。然而，关于与 SARS-CoV-2 感染有时间关联的肺炎链球菌感染的研究有限。我们描述了 2020 年 1 月 1 日至 2021 年 12 月 23 日期间，美国阿拉斯加发生的与 SARS-CoV-2 感染有时间关联的侵袭性肺炎球菌病（IPD）患者的流行病学和临床经过。在 271 例经实验室确诊的 IPD 患者中，有 55 例（20%）的 SARS-CoV-2 检测结果呈阳性。我们发现，有无 SARS-CoV-2 的 IPD 患者在年龄、种族、性别或基础疾病方面无显著差异。然而，有 SARS-CoV-2 的 IPD 患者死亡比例（16%，n=9）高于单纯 IPD 患者（4%，n=9）（p<0.01）。有 SARS-CoV-2 的 IPD 患者更有可能无家可归（调整后的比值比 3.5；95%CI 1.7-7.5）。我们的研究强调了双重感染的风险，以及肺炎球菌和 COVID-19 疫苗接种的持续获益，特别是在弱势群体中。
