Zhang Zhi, Deng Jing-Tong, Feng Jia-Yi, Liang Jin-Yan, Xu Xue-Tao, Peng Jin-Bao
School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529020, P. R. China.
J Org Chem. 2023 Aug 18;88(16):12054-12063. doi: 10.1021/acs.joc.3c01451. Epub 2023 Jul 28.
A palladium catalyzed annulation of -iodo-anilines with propargyl alcohols for the synthesis of substituted quinolines has been developed. The reaction tolerates diverse functional groups under mild conditions, providing direct access to 2,4-disubstituted quinolines from easily available starting materials. A broad range of 2,4-disubstituted quinolines were efficiently prepared in good to excellent yields.
已开发出一种钯催化的碘代苯胺与炔丙醇环化反应以合成取代喹啉。该反应在温和条件下能耐受多种官能团，可从容易获得的起始原料直接制得2,4-二取代喹啉。一系列2,4-二取代喹啉得以高效制备，产率良好至优异。
