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二项式-离散爱尔朗截断指数混合模型及其在癌症疾病中的应用。

Binomial-discrete Erlang-truncated exponential mixture and its application in cancer disease.

机构信息

Department of Mathematics, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Department of Statistics, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia.

出版信息

Sci Rep. 2023 Jul 28;13(1):12229. doi: 10.1038/s41598-023-38709-2.

Abstract

Among diseases, cancer exhibits the fastest global spread, presenting a substantial challenge for patients, their families, and the communities they belong to. This paper is devoted to modeling such a disease as a special case. A newly proposed distribution called the binomial-discrete Erlang-truncated exponential (BDETE) is introduced. The BDETE is a mixture of binomial distribution with the number of trials (parameter [Formula: see text]) taken after a discrete Erlang-truncated exponential distribution. A comprehensive mathematical treatment of the proposed distribution and expressions of its density, cumulative distribution function, survival function, failure rate function, Quantile function, moment generating function, Shannon entropy, order statistics, and stress-strength reliability, are provided. The distribution's parameters are estimated using the maximum likelihood method. Two real-world lifetime count data sets from the cancer disease, both of which are right-skewed and over-dispersed, are fitted using the proposed BDETE distribution to evaluate its efficacy and viability. We expect the findings to become standard works in probability theory and its related fields.

摘要

在所有疾病中,癌症的全球传播速度最快,给患者、患者家属以及他们所在的社区带来了巨大的挑战。本文致力于将此类疾病作为一个特例进行建模。引入了一种新的分布,称为二项离散爱尔朗截断指数分布(BDETE)。BDETE 是二项分布与离散爱尔朗截断指数分布后取的试验次数(参数 [Formula: see text])的混合。对所提出的分布进行了全面的数学处理,并给出了其密度、累积分布函数、生存函数、失效率函数、分位数函数、矩生成函数、Shannon 熵、顺序统计量和应力-强度可靠性的表达式。使用最大似然法估计分布的参数。使用所提出的 BDETE 分布拟合了来自癌症疾病的两个真实的寿命计数数据集,这两个数据集都是右偏和过分散的,以评估其有效性和可行性。我们希望这些发现成为概率论及其相关领域的标准著作。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b9c/10382481/3327077d3ef1/41598_2023_38709_Fig1_HTML.jpg

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