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SIRT1-NLRP3 通路在炎症反应中的作用。

Involvement of the SIRT1-NLRP3 pathway in the inflammatory response.

机构信息

Department of Clinical Pharmacy, the First Hospital of Jilin University, Changchun, , Jilin, China.

School of Pharmaceutical Science, Jilin University, Changchun, Jilin, China.

出版信息

Cell Commun Signal. 2023 Jul 28;21(1):185. doi: 10.1186/s12964-023-01177-2.

DOI:10.1186/s12964-023-01177-2
PMID:37507744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10375653/
Abstract

The silent information regulator 2 homolog 1-NACHT, LRR and PYD domains-containing protein 3 (SIRT1-NLRP3) pathway has a crucial role in regulation of the inflammatory response, and is closely related to the occurrence and development of several inflammation-related diseases. NLRP3 is activated to produce the NLRP3 inflammasome, which leads to activation of caspase-1 and cleavage of pro-interleukin (IL)-1β and pro-IL-18 to their active forms: IL-1β and IL-18, respectively. They are proinflammatory cytokines which then cause an inflammatory response.SIRT1 can inhibit this inflammatory response through nuclear factor erythroid 2-related factor 2 and nuclear factor-kappa B pathways. This review article focuses mainly on how the SIRT1-NLRP3 pathway influences the inflammatory response and its relationship with melatonin, traumatic brain injury, neuroinflammation, depression, atherosclerosis, and liver damage. Video Abstract.

摘要

沉默信息调节因子 2 同源物 1-NACHT、LRR 和 PYD 结构域包含蛋白 3（SIRT1-NLRP3）途径在调节炎症反应中具有关键作用，并且与几种炎症相关疾病的发生和发展密切相关。NLRP3 被激活以产生 NLRP3 炎性小体，导致半胱天冬酶-1 的激活和前白细胞介素 (IL)-1β 和前白细胞介素 (IL)-18 的切割为其活性形式：IL-1β 和 IL-18，分别。它们是促炎细胞因子，然后引起炎症反应。SIRT1 可以通过核因子红细胞 2 相关因子 2 和核因子-κB 途径抑制这种炎症反应。本文主要综述了 SIRT1-NLRP3 途径如何影响炎症反应及其与褪黑素、创伤性脑损伤、神经炎症、抑郁、动脉粥样硬化和肝损伤的关系。视频摘要。

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J Pain Res. 2025-8-27

[2]
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Int J Mol Sci. 2025-8-3

[3]
Dexpanthenol attenuates brain injury following pulmonary ischemia/reperfusion: modulation of oxidative stress, inflammation, and apoptotic pathways.

Mol Biol Rep. 2025-7-16

[4]
JC124 confers multimodal neuroprotection in epilepsy by suppressing NLRP3 inflammasome activation: evidence from animal and human neuronal models.

Cell Commun Signal. 2025-7-8

[5]
The age-dependent impacts of treadmill exercise on cognitive impairments by reducing inflammation and oxidative stress in the hippocampus of morphine-exposed rats: the role of SIRTs 3 &4 and BDNF.

Biogerontology. 2025-5-26

[6]
PGC-1α agonist ZLN005 ameliorates OVA-induced asthma in BALB/c mice through modulating the NF-κB-p65/NLRP3 pathway.

Iran J Basic Med Sci. 2025

[7]
Salidroside impedes Ang II-infused myocardial fibrosis by activating the SIRT1-Nrf2 pathway.

Iran J Basic Med Sci. 2025

[8]
exerts cardioprotective effect post myocardial infarction by attenuating myocardial fibrosis and inflammation through SIRT1 signaling pathways.

J Ginseng Res. 2025-3

[9]
Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review).

Biomed Rep. 2025-1-14

[10]
Extraction, detection, bioactivity, and product development of luteolin: A review.

Heliyon. 2024-12-7

本文引用的文献

[1]
The SIRT1-HMGB1 axis: Therapeutic potential to ameliorate inflammatory responses and tumor occurrence.

Front Cell Dev Biol. 2022-8-19

[2]
Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior Regulation of SIRT1-NLRP3/Nrf2 Pathways.

Front Nutr. 2022-5-12

[3]
Cucurbitacin E glucoside alleviates concanavalin A-induced hepatitis through enhancing SIRT1/Nrf2/HO-1 and inhibiting NF-ĸB/NLRP3 signaling pathways.

J Ethnopharmacol. 2022-6-28

[4]
Terretonin as a New Protective Agent against Sepsis-Induced Acute Lung Injury: Impact on SIRT1/Nrf2/NF-κBp65/NLRP3 Signaling.

Biology (Basel). 2021-11-22

[5]
Huaiqihuang (HQH) granule alleviates cyclophosphamide-induced nephrotoxicity via suppressing the MAPK/NF-κB pathway and NLRP3 inflammasome activation.

Pharm Biol. 2021-12

[6]
Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3.

J Biochem Mol Toxicol. 2021-11

[7]
Anti-Inflammatory Activity of Melatonin: a Focus on the Role of NLRP3 Inflammasome.

Inflammation. 2021-8

[8]
The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease.

Front Neurol. 2020-9-18

[9]
Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway.

Toxicology. 2020-5-11

[10]
Resveratrol Mitigates Sevoflurane-Induced Neurotoxicity by the SIRT1-Dependent Regulation of BDNF Expression in Developing Mice.

Oxid Med Cell Longev. 2020-2-18

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