El Sherbiny Samar, Squillacioti Giulia, Colombi Nicoletta, Ghelli Federica, Lenta Elena, Dalla Costa Cloè, Bono Roberto
Department of Public Health and Pediatrics, University of Turin, 10126 Turin, Italy.
Biblioteca Federata di Medicina Ferdinando Rossi, University of Turin, 10126 Turin, Italy.
Antioxidants (Basel). 2023 Jul 15;12(7):1427. doi: 10.3390/antiox12071427.
During pregnancy, reactive oxygen species (ROS) may physiologically increase due to changes and growth of mother and fetal tissues. Consequently, oxidative stress (OS) may occur and be involved in the onset of pregnancy and newborn complications. Among exogenous antioxidant sources, diet is a cost-effective prevention strategy supporting the health of mothers and newborns; however, there is still a lack of nutritional education during pregnancy interviews. This review aims to systematically summarize the knowledge on the association between OS and diet during pregnancy. Four electronic databases (PubMed Central, EMBASE, Web of Science, and Food Science and Technology Abstracts) were searched on 22 December 2022. Among 4162 records, 13 original articles were finally included. Overall, 80% of the studies considered dietary patterns as exposure and 60% of them assessed the association with malondialdehyde levels in blood and urine. Three studies analyzed the influence of daily intakes of fruit and vegetables on different OS biomarkers (malondialdehyde, nitric oxide and 8-hydroxy-2'-deoxyguanosine). Among studies exploring dietary fat intakes (39%), 80% focused on polyunsaturated fatty acids, finding a positive association with glutathione peroxidase, biopirryn and isoprostane levels, respectively. Four studies analyzed vitamin intakes and 50% of them in association with 8-hydroxy-2'-deoxyguanosine.
在孕期，由于母体和胎儿组织的变化与生长，活性氧（ROS）可能会生理性增加。因此，可能会发生氧化应激（OS），并与妊娠和新生儿并发症的发生有关。在外部抗氧化剂来源中，饮食是一种支持母亲和新生儿健康的经济有效的预防策略；然而，在孕期访谈中仍然缺乏营养教育。本综述旨在系统总结孕期氧化应激与饮食之间关联的相关知识。于2022年12月22日检索了四个电子数据库（PubMed Central、EMBASE、Web of Science和食品科学与技术文摘）。在4162条记录中，最终纳入了13篇原创文章。总体而言，80%的研究将饮食模式视为暴露因素，其中60%评估了与血液和尿液中丙二醛水平的关联。三项研究分析了水果和蔬菜每日摄入量对不同氧化应激生物标志物（丙二醛、一氧化氮和8-羟基-2'-脱氧鸟苷）的影响。在探索膳食脂肪摄入量的研究中（39%），80%关注多不饱和脂肪酸，分别发现与谷胱甘肽过氧化物酶、生物吡啉和异前列腺素水平呈正相关。四项研究分析了维生素摄入量，其中50%与8-羟基-2'-脱氧鸟苷有关。
