Diaz-Garcia Hector, Vilchis-Gil Jenny, Garcia-Roca Pilar, Klünder-Klünder Miguel, Gomez-Lopez Jacqueline, Granados-Riveron Javier T, Sanchez-Urbina Rocio
Unidad de Investigación en Malformaciones Congénitas, Hospital Infantil de Mexico Federico Gómez, Mexico City 06720, Mexico.
Sección de Estudios de Posgrado e Investigación de la Escuela Superior de Medicina del Instituto Politécnico Nacional, Mexico City 11340, Mexico.
Life (Basel). 2022 Jul 8;12(7):1012. doi: 10.3390/life12071012.
During pregnancy, appropriate nutritional support is necessary for the development of the foetus. Maternal nutrition might protect the foetus from toxic agents such as free radicals due to its antioxidant content. In this study, 90 mothers and their children were recruited. DNA damage mediated by oxidative stress (OS) was determined by the levels of 8-hidroxy-2′-deoxyguanosine (8-OHdG) in the plasma of women and umbilical cord blood. The mothers and newborns were categorised into tertiles according to their 8-OHdG levels for further comparison. No relevant clinical differences were observed in each group. A strong correlation was observed in the mother−newborn binomial for 8-OHdG levels (Rho = 0.694, p < 0.001). In the binomial, a lower level of 8-OHdG was associated with higher consumption of calories, carbohydrates, lipids, and vitamin A (p < 0.05). In addition, the levels of 8-OHdG were only significantly lower in newborns from mothers with a higher consumption of vitamin A and E (p < 0.01). These findings were confirmed by a significant negative correlation between the 8-OHdG levels of newborns and the maternal consumption of vitamins A and E, but not C (Rho = −0.445 (p < 0.001), −0.281 (p = 0.007), and −0.120 (p = 0.257), respectively). Multiple regression analysis showed that the 8-OHdG levels in mothers and newborns inversely correlated with vitamin A (β = −1.26 (p = 0.016) and −2.17 (p < 0.001), respectively) and pregestational body mass index (β = −1.04 (p = 0.007) and −0.977 (p = 0.008), respectively). In conclusion, maternal consumption of vitamins A and E, but not C, might protect newborns from DNA damage mediated by OS.
孕期，适当的营养支持对胎儿发育至关重要。母体营养因其抗氧化成分，可能保护胎儿免受自由基等有毒物质的侵害。本研究招募了90位母亲及其子女。通过检测女性血浆和脐带血中8-羟基-2'-脱氧鸟苷（8-OHdG）水平，确定氧化应激（OS）介导的DNA损伤。根据母亲和新生儿的8-OHdG水平将其分为三个三分位数组，以便进一步比较。各组间未观察到相关临床差异。母亲-新生儿二元组中8-OHdG水平呈现强相关性（Rho = 0.694，p < 0.001）。在该二元组中，较低的8-OHdG水平与较高的卡路里、碳水化合物、脂质和维生素A摄入量相关（p < 0.05）。此外，只有母亲维生素A和E摄入量较高的新生儿，其8-OHdG水平才显著较低（p < 0.01）。新生儿8-OHdG水平与母亲维生素A和E而非维生素C的摄入量之间存在显著负相关，证实了上述发现（Rho分别为−0.445（p < 0.001）、−0.281（p = 0.007）和−0.120（p = 0.257））。多元回归分析表明，母亲和新生儿的8-OHdG水平与维生素A呈负相关（β分别为−1.26（p = 0.016）和−2.17（p < 0.001）），与孕前体重指数也呈负相关（β分别为−1.04（p = 0.007）和−0.977（p = 0.008））。总之，母亲摄入维生素A和E而非维生素C，可能保护新生儿免受OS介导的DNA损伤。
