孕期饮食模式与母亲及后代氧化应激生物标志物：NELA出生队列研究
Dietary Patterns in Pregnancy and Biomarkers of Oxidative Stress in Mothers and Offspring: The NELA Birth Cohort.
作者信息
Morales Eva, García-Serna Azahara M, Larqué Elvira, Sánchez-Campillo María, Serrano-Munera Ana, Martinez-Graciá Carmen, Santaella-Pascual Marina, Suárez-Martínez Clara, Vioque Jesús, Noguera-Velasco José A, Avilés-Plaza Francisco V, Martínez-Villanueva Miriam, Ballesteros-Meseguer Carmen, Galdo-Castiñeira Lina, García-Marcos Luis
机构信息
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain.
出版信息
Front Nutr. 2022 Apr 12;9:869357. doi: 10.3389/fnut.2022.869357. eCollection 2022.
BACKGROUND
Although adherence to the Mediterranean and antioxidant-rich diets during pregnancy is suggested to improve maternal-fetal health by reducing oxidative stress, yet there is no study available.
OBJECTIVE
We examined whether maternal dietary patterns in pregnancy impact the biomarkers of oxidative stress in mothers and their offspring.
METHODS
Study population included 642 mothers and 335 newborns of the "Nutrition in Early Life and Asthma" (NELA) birth cohort. Maternal diet during pregnancy was assessed by a validated food frequency questionnaire and -defined dietary indices (relative Mediterranean Diet [rMED], alternative Mediterranean Diet [aMED], Dietary Approach to Stop Hypertension [DASH], Alternate Healthy Index [AHEI], and AHEI-2010) were calculated. Biomarkers measured were: hydroperoxides, carbonyl groups, and 8-hydroxydeoxyguanosine (8OHdG) determined in maternal blood and newborn cord blood, and urinary maternal and offspring 15-F2t-isoprostane. Multivariate linear regression models were performed.
RESULTS
Maternal rMED score was inversely associated with the maternal levels of 8OHdG at mid-pregnancy (beta per 1-point increase = -1.61; 95% -2.82, -0.39) and the newborn levels of hydroperoxides (beta per 1-point increase = -4.54; 95% -9.32, 0.25). High vs. low maternal rMED score was marginally associated with the decreased levels of 8OHdG in newborns (beta = -9.17; 95% -19.9, 1.63; for trend 0.079). Maternal DASH score tended to be inversely associated with maternal urinary 15-F2t-isoprostane (beta per 1-point increase = -0.69; 95% , -1.44, 0.06). High vs. low maternal AHEI score was associated with reduced offspring urinary levels of 15-F2t-isoprostane (beta = -20.2; 95% -38.0, -2.46; for trend 0.026).
CONCLUSION
These results suggest that maternal adherence to healthy dietary patterns during pregnancy may reduce DNA damage and lipid oxidation in mothers and offspring.
背景
尽管建议孕期坚持地中海饮食和富含抗氧化剂的饮食可通过减轻氧化应激来改善母婴健康，但尚无相关研究。
目的
我们研究了孕期母亲的饮食模式是否会影响母亲及其后代氧化应激的生物标志物。
方法
研究人群包括“生命早期营养与哮喘”（NELA）出生队列中的642名母亲和335名新生儿。通过经过验证的食物频率问卷评估孕期母亲的饮食，并计算定义的饮食指数（相对地中海饮食[rMED]、替代地中海饮食[aMED]、终止高血压饮食方法[DASH]、替代健康指数[AHEI]和AHEI-2010）。测量的生物标志物包括：母亲血液和新生儿脐带血中测定的氢过氧化物、羰基和8-羟基脱氧鸟苷（8OHdG），以及母亲和后代尿液中的15-F2t-异前列腺素。进行多变量线性回归模型分析。
结果
母亲的rMED评分与孕中期母亲的8OHdG水平呈负相关（每增加1分的β=-1.61；95%可信区间 -2.⑧2，-0.39）以及新生儿的氢过氧化物水平呈负相关（每增加1分的β=-4.54；95%可信区间 -9.32，0.25）。母亲rMED评分高与低相比，与新生儿8OHdG水平降低有边缘性关联（β=-9.17；95%可信区间 -19.9，1.63；趋势P=0.079）。母亲的DASH评分倾向于与母亲尿液中的15-F2t-异前列腺素呈负相关（每增加1分的β=-0.69；95%可信区间 ，-1.44，0.06）。母亲AHEI评分高与低相比，与后代尿液中15-F2t-异前列腺素水平降低有关（β=-20.2；95%可信区间 -38.0，-2.46；趋势P=0.026）。
结论
这些结果表明，孕期母亲坚持健康的饮食模式可能会减少母亲和后代的DNA损伤和脂质氧化。
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