野生鸭和海鸥中甲型流感病毒的多样性和重组率。
Diversity and Reassortment Rate of Influenza A Viruses in Wild Ducks and Gulls.
机构信息
Chumakov Federal Scientific Center for the Research and Development of Immune-and-Biological Products, Village of Institute of Poliomyelitis, Settlement "Moskovskiy", 108819 Moscow, Russia.
Institute of Virology, Philipps University, Hans-Meerwein-Str. 2, D-35043 Marburg, Germany.
出版信息
Viruses. 2021 May 27;13(6):1010. doi: 10.3390/v13061010.
Influenza A viruses (IAVs) evolve via point mutations and reassortment of viral gene segments. The patterns of reassortment in different host species differ considerably. We investigated the genetic diversity of IAVs in wild ducks and compared it with the viral diversity in gulls. The complete genomes of 38 IAVs of H1N1, H1N2, H3N1, H3N2, H3N6, H3N8, H4N6, H5N3, H6N2, H11N6, and H11N9 subtypes isolated from wild mallard ducks and gulls resting in a city pond in Moscow, Russia were sequenced. The analysis of phylogenetic trees showed that stable viral genotypes do not persist from year to year in ducks owing to frequent gene reassortment. For comparison, similar analyses were carried out using sequences of IAVs isolated in the same period from ducks and gulls in The Netherlands. Our results revealed a significant difference in diversity and rates of reassortment of IAVs in ducks and gulls.
甲型流感病毒（IAV）通过点突变和病毒基因片段的重配进化。不同宿主物种中的重配模式有很大的不同。我们研究了野鸭中 IAV 的遗传多样性，并将其与海鸥中的病毒多样性进行了比较。从俄罗斯莫斯科市一个池塘中栖息的野鸭和海鸥中分离出的 38 株 H1N1、H1N2、H3N1、H3N2、H3N6、H3N8、H4N6、H5N3、H6N2、H11N6 和 H11N9 亚型的 IAV，其完整基因组被测序。系统进化树分析表明，由于频繁的基因重配，稳定的病毒基因型不会在鸭中持续存在一年又一年。为了进行比较，我们还使用了同一时期在荷兰从鸭和海鸥中分离出的 IAV 序列进行了类似的分析。我们的结果显示，鸭和海鸥中 IAV 的多样性和重配率存在显著差异。
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