Cubeddu Francesca, Masala Gerolamo, Sotgiu Giovanni, Mollica Alessandra, Versace Sylvia, Careddu Giovanni Mario
Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100 Sassari, Italy.
Department of Surgical and Experimental Medical Sciences Medicine, Surgery and Pharmacy, University of Sassari, Viale San Pietro 43, 07100 Sassari, Italy.
Animals (Basel). 2023 Jul 23;13(14):2388. doi: 10.3390/ani13142388.
General anesthesia for ovariectomy in dogs is based on a balanced anesthesia protocol such as using analgesics along with an inhalant agent. While opioids such as fentanyl and methadone are commonly used for their analgesic potency, other drugs can also have analgesic effects. Maropitant, an antiemetic for dogs and cats, has also been shown to exert analgesic effects, especially on visceral pain. The aim of this study was to compare the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. Two groups of 20 healthy mixed-breeds bitches undergoing elective ovariectomy received intravenous either maropitant at antiemetic dose of 1 mg kg or methadone at the dose of 0.3 mg kg. Cardiorespiratory variables were collected before premedication, 10 min after sedation and during surgery. Recovery quality and postoperative pain were evaluated 15, 30, 60, 120, 240 and 360 min postoperatively. Results showed that maropitant produced analgesia and reduced the requirement of desflurane in amounts similar to those determined by methadone (5.39 ± 0.20% and 4.91 ± 0.26%, respectively) without significant difference, while maintaining heart rate, arterial blood pressure, respiratory rate and carbon dioxide end-tidal partial pressure even at a more satisfactory level. Therefore, maropitant may be recommended as an analgesic drug for abdominal surgery not only in healthy dogs but also in those with reduced cardiorespiratory compensatory capacities or at risk of hypotension, especially when combined with a sedative such as dexmedetomidine.
犬卵巢切除术的全身麻醉基于平衡麻醉方案，如联合使用镇痛药和吸入麻醉剂。虽然芬太尼和美沙酮等阿片类药物因其镇痛效力而常用，但其他药物也可能具有镇痛作用。马罗匹坦是一种用于犬猫的止吐药，也已显示出具有镇痛作用，尤其是对内脏痛。本研究的目的是比较马罗匹坦和美沙酮联合地氟醚对接受卵巢切除术的犬的心肺效应和镇痛特性。两组20只接受择期卵巢切除术的健康杂种母犬，分别静脉注射1 mg/kg止吐剂量的马罗匹坦或0.3 mg/kg剂量的美沙酮。在术前用药前、镇静后10分钟和手术期间收集心肺变量。在术后15、30、60、120、240和360分钟评估恢复质量和术后疼痛。结果表明，马罗匹坦产生的镇痛效果以及减少地氟醚用量的程度与美沙酮相似（分别为5.39±0.20%和4.91±0.26%），无显著差异，同时即使在更令人满意的水平下也能维持心率、动脉血压、呼吸频率和呼气末二氧化碳分压。因此，马罗匹坦不仅可推荐用于健康犬的腹部手术，也可用于心肺代偿能力降低或有低血压风险的犬，特别是与右美托咪定等镇静剂联合使用时。
