Zaghen Francesca, Sora Valerio Massimo, Meroni Gabriele, Laterza Giulia, Martino Piera Anna, Soggiu Alessio, Bonizzi Luigi, Zecconi Alfonso
Department of Biomedical, Surgical and Dental Sciences-One Health Unit, School of Medicine, University of Milan, Via Pascal 36, 20133 Milan, Italy.
Department of Clinical and Community Sciences, School of Medicine, University of Milan, Via Celoria 22, 20133 Milan, Italy.
Antibiotics (Basel). 2023 Jul 24;12(7):1225. doi: 10.3390/antibiotics12071225.
is considered one of the most widespread bacterial pathogens for both animals and humans, being the causative agent of various diseases like food poisoning, respiratory tract infections, nosocomial bacteremia, and surgical site and cardiovascular infections in humans, as well as clinical and subclinical mastitis, dermatitis, and suppurative infections in animals. Thanks to their genetic flexibility, several virulent and drug-resistant strains have evolved mainly due to horizontal gene transfer and insurgence of point mutations. Infections caused by the colonization of such strains are particularly problematic due to frequently occurring antibiotic resistance, particulary methicillin-resistant (MRSA), and are characterized by increased mortality, morbidity, and hospitalization rates compared to those caused by methicillin-sensitive (MSSA). infections in humans and animals are a prime example of a disease that may be managed by a One Health strategy. In fact, is a significant target for control efforts due to its zoonotic potential, the frequency of its illnesses in both humans and animals, and the threat posed by antibiotic resistance globally. The results of an epidemiological analysis on a worldwide public database (NCBI Pathogen Detection Isolate Browser; NPDIB) of 35,026 isolates were described. We considered the diffusion of antibiotic resistance genes (ARGs), in both human and animal setting, and the results may be considered alarming. The result of this study allowed us to identify the presence of clusters with specific ARG patterns, and that these clusters are associated with different sources of isolation (e.g., human, non-human).
被认为是动物和人类中分布最广泛的细菌病原体之一，是多种疾病的病原体，如食物中毒、呼吸道感染、医院获得性菌血症、人类手术部位感染和心血管感染，以及动物的临床和亚临床乳腺炎、皮炎和化脓性感染。由于它们的遗传灵活性，主要通过水平基因转移和点突变的出现，已经进化出了几种有毒力和耐药性的菌株。由这些菌株定植引起的感染特别成问题，因为经常出现抗生素耐药性，尤其是耐甲氧西林（MRSA），与甲氧西林敏感（MSSA）引起的感染相比，其死亡率、发病率和住院率都有所增加。人和动物中的感染是一种可以通过“同一健康”战略来管理的疾病的主要例子。事实上，由于其人畜共患病潜力、在人类和动物中发病的频率以及全球抗生素耐药性构成的威胁，它是控制工作的一个重要目标。描述了对全球公共数据库（NCBI病原体检测分离株浏览器；NPDIB）中35026株分离株进行的流行病学分析结果。我们考虑了抗生素耐药基因（ARGs）在人类和动物环境中的传播情况，结果可能令人担忧。这项研究的结果使我们能够识别出具有特定ARGs模式的簇的存在，并且这些簇与不同的分离来源（如人类、非人类）相关。
