Fascin在树突状细胞中的作用。

Roles of Fascin in Dendritic Cells.

作者信息

Wang Hao-Jie, Jiang Ya-Ping, Zhang Jun-Ying, Tang Xiao-Qi, Lou Jian-Shu, Huang Xin-Yun

机构信息

School of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines, Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou 311121, China.

出版信息

Cancers (Basel). 2023 Jul 20;15(14):3691. doi: 10.3390/cancers15143691.

DOI:10.3390/cancers15143691

PMID:37509352

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10378208/

Abstract

Dendritic cells (DCs) are professional antigen-presenting cells that play a crucial role in activating naive T cells through presenting antigen information, thereby influencing immunity and anti-cancer responses. Fascin, a 55-kDa actin-bundling protein, is highly expressed in mature DCs and serves as a marker protein for their identification. However, the precise role of fascin in intratumoral DCs remains poorly understood. In this review, we aim to summarize the role of fascin in both normal and intratumoral DCs. In normal DCs, fascin promotes immune effects through facilitating DC maturation and migration. Through targeting intratumoral DCs, fascin inhibitors enhance anti-tumor immune activity. These roles of fascin in different DC populations offer valuable insights for future research in immunotherapy and strategies aimed at improving cancer treatments.

摘要

树突状细胞（DCs）是专职抗原呈递细胞，通过呈递抗原信息在激活初始T细胞中发挥关键作用，从而影响免疫和抗癌反应。Fascin是一种55 kDa的肌动蛋白捆绑蛋白，在成熟DCs中高度表达，可作为其鉴定的标志物蛋白。然而，Fascin在肿瘤内DCs中的具体作用仍知之甚少。在本综述中，我们旨在总结Fascin在正常和肿瘤内DCs中的作用。在正常DCs中，Fascin通过促进DC成熟和迁移来增强免疫效应。通过靶向肿瘤内DCs，Fascin抑制剂可增强抗肿瘤免疫活性。Fascin在不同DC群体中的这些作用为免疫治疗及旨在改善癌症治疗的策略的未来研究提供了有价值的见解。