Ubbink Rinse, Streng Lucia W J M, Raat Nicolaas J H, Harms Floor A, Te Boekhorst Peter A W, Stolker Robert J, Mik Egbert G
Laboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Department of Hematology, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Biomedicines. 2023 Jun 30;11(7):1873. doi: 10.3390/biomedicines11071873.
In light of the associated risks, the question has been raised whether the decision to give a blood transfusion should solely be based on the hemoglobin level. As mitochondria are the final destination of oxygen transport, mitochondrial parameters are suggested to be of added value. The aims of this pilot study were to investigate the effect of a red blood cell transfusion on mitochondrial oxygenation as measured by the COMET device in chronic anemia patients and to explore the clinical usability of the COMET monitor in blood transfusion treatments, especially the feasibility of performing measurements in an outpatient setting. To correct the effect of volume load on mitochondrial oxygenation, a red blood cell transfusion and a saline infusion were given in random order. In total, 21 patients were included, and this resulted in 31 observations. If patients participated twice, the order of infusion was reversed. In both the measurements wherein a blood transfusion was given first and wherein 500 mL of 0.9% saline was given first, the median mitochondrial oxygen tension decreased after red blood cell transfusion. The results of this study have strengthened the need for further research into the effect of blood transfusion tissue oxygenation and the potential role of mitochondrial parameters herein.
鉴于相关风险，有人提出输血决策是否应仅基于血红蛋白水平这一问题。由于线粒体是氧运输的最终目的地，线粒体参数被认为具有附加价值。这项初步研究的目的是调查红细胞输血对慢性贫血患者通过COMET设备测量的线粒体氧合的影响，并探索COMET监测仪在输血治疗中的临床实用性，特别是在门诊环境中进行测量的可行性。为了纠正容量负荷对线粒体氧合的影响，红细胞输血和生理盐水输注按随机顺序进行。总共纳入了21名患者，共进行了31次观察。如果患者参与两次，则输注顺序颠倒。在首先进行输血的测量以及首先输注500 mL 0.9%生理盐水的测量中，红细胞输血后线粒体氧张力中位数均下降。这项研究的结果进一步表明，有必要进一步研究输血对组织氧合的影响以及线粒体参数在其中的潜在作用。
